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(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
还可以产品编号 T40161Cas号 250214-40-5
别名 (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochloride
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions.
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
还可以产品编号 T40161 别名 (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochlorideCas号 250214-40-5
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 1,150 | 5日内发货 |
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| 产品描述 | (Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i values) for M1, M2, M3, M4, and M5 receptors, with values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM, respectively. This compound is commonly employed in research related to overactive bladder conditions. |
| 体外活性 | In vitro, (Rac)-5-Hydroxymethyl Tolterodine (PNU-200577) hydrochloride produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips (K B of 0.84 nM; pA2 of 9.14)[2]. |
| 体内活性 | (Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) hydrochloride treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine hydrochloride to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3]. |
| 别名 | (Rac)-PNU-200577hydrochloride, (Rac)-Desfesoterodine hydrochloride, (Rac)-5-Hydroxymethyl Tolterodine hydrochloride |
| 分子量 | 377.95 |
| 分子式 | C22H32ClNO2 |
| CAS No. | 250214-40-5 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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