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Clofarabine-5'-diphosphate (Clofarabine-DP) 是 Clofarabine 经脱氧胞苷激酶 (dCK) 磷酸化后的代谢产物。Clofarabine-5'-diphosphate 还能继续磷酸化生成 Clofarabine-5'-triphosphate,在癌细胞中通过阻碍 DNA 合成和 DNA 修复展现出细胞毒性。
Clofarabine-5'-diphosphate (Clofarabine-DP) 是 Clofarabine 经脱氧胞苷激酶 (dCK) 磷酸化后的代谢产物。Clofarabine-5'-diphosphate 还能继续磷酸化生成 Clofarabine-5'-triphosphate,在癌细胞中通过阻碍 DNA 合成和 DNA 修复展现出细胞毒性。
产品描述 | Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair. |
别名 | Clofarabine-DP |
分子量 | 463.64 |
分子式 | C10H13ClFN5O9P2 |
CAS No. | 167620-89-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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