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β-Cateninmodulator-7 (Compound 5) 作为β-catenin的调节剂,能够在HCT-116细胞的细胞质和细胞核中抑制β-catenin的表达,并抑制GSK 3β的磷酸化.此外,该化合物能够促进NO在HCT-116细胞中的释放,有效抑制这些癌细胞的增殖,其IC50值介于0.6-0.9 μM之间.因此,β-Cateninmodulator-7主要用于结肠癌的相关研究.
β-Cateninmodulator-7 (Compound 5) 作为β-catenin的调节剂,能够在HCT-116细胞的细胞质和细胞核中抑制β-catenin的表达,并抑制GSK 3β的磷酸化.此外,该化合物能够促进NO在HCT-116细胞中的释放,有效抑制这些癌细胞的增殖,其IC50值介于0.6-0.9 μM之间.因此,β-Cateninmodulator-7主要用于结肠癌的相关研究.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | β-Cateninmodulator-7 (Compound 5) acts as a regulator of β-catenin. It suppresses the expression of β-catenin in both the cytoplasm and nucleus of HCT-116 cells and inhibits the phosphorylation of GSK 3β. Additionally, β-Cateninmodulator-7 facilitates the release of NO in HCT-116 cells and inhibits the proliferation of these cancer cells, with an IC50 value of 0.6-0.9 μM. This compound is utilized in research related to colon cancer. |
分子量 | 583.03 |
分子式 | C26H35ClN4O9 |
CAS No. | 2892294-93-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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