Arotinolol hydrochloride

产品编号 T30140Cas号 68377-91-3

别名 Arotinolol HCl|||阿罗洛尔盐酸盐

Arotinolol hydrochloride（Arotinolol HCl）是一种非选择性的 α/β-肾上腺素受体 (α/β-adrenergic receptor ) 阻滞剂。Arotinolol hydrochloride 对放射性配体 125I-ICYP 与 5HT1B-羟色胺受体能结合有抑制作用。Arotinolol hydrochloride 是一种抗高血压和抗肥胖试剂，可改善大鼠主动脉僵硬，研究肥胖相关疾病。

Arotinolol hydrochloride

产品编号 T30140别名 Arotinolol HCl, 阿罗洛尔盐酸盐Cas号 68377-91-3

规格	价格	库存
1 mg	¥ 343	现货
5 mg	¥ 768	现货
10 mg	¥ 1,130	现货
25 mg	¥ 1,890	现货
50 mg	¥ 2,780	现货
100 mg	¥ 4,130	现货
500 mg	¥ 8,780	现货

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产品介绍

生物活性

产品描述	Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.
体外活性	Arotinolol HCl shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol HCl displaces 125I-ICYP binding to 5HT1B-receptors with the pKi values of 7.97 and 8.16 respectively for β1 and β2 adrenergic receptors.[3] Arotinolol HCl shows its selectivity of β-adrenergic receptors, the result of Arotinolol HCl for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. The selective of β1 and β2 is equal.[3]
体内活性	Arotinolol HCl (200 mg/kg; oral gavage; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mice.[3]
别名	Arotinolol HCl, 阿罗洛尔盐酸盐

化学信息

分子量	408
分子式	C₁₅H₂₂ClN₃O₂S₃
CAS No.	68377-91-3

储存&溶解度

存储

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 55 mg/mL (134.8 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4510 mL	12.2549 mL	24.5098 mL	122.5490 mL
5 mM	0.4902 mL	2.4510 mL	4.9020 mL	24.5098 mL
10 mM	0.2451 mL	1.2255 mL	2.4510 mL	12.2549 mL
20 mM	0.1225 mL	0.6127 mL	1.2255 mL	6.1275 mL
50 mM	0.0490 mL	0.2451 mL	0.4902 mL	2.4510 mL
100 mM	0.0245 mL	0.1225 mL	0.2451 mL	1.2255 mL