PEG5-Tos

Name: PEG5-Tos
Brand: TargetMol
SKU: T16462
Rating: 4.5 (1 reviews)

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产品编号 T16462Cas号 155130-15-7

PEG5-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG5-Tos

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产品编号 T16462Cas号 155130-15-7

规格	价格	库存	数量
100 mg	¥ 429	5日内发货

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产品介绍

生物活性

产品描述	PEG5-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
体外活性	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

化学信息

分子量	392.46
分子式	C₁₇H₂₈O₈S
CAS No.	155130-15-7
密度	1.206 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 100 mg/mL (254.80 mM), Sonication is recommended.

DMSO: 100 mg/mL (254.80 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5480 mL	12.7402 mL	25.4803 mL	127.4015 mL
5 mM	0.5096 mL	2.5480 mL	5.0961 mL	25.4803 mL
10 mM	0.2548 mL	1.2740 mL	2.5480 mL	12.7402 mL
20 mM	0.1274 mL	0.6370 mL	1.2740 mL	6.3701 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5480 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2740 mL