Gastrofensin AN 5 free base, is an antiulcer agent. a 4-phenyl-tetrahydroisoquinoline derivative.

Gastrofensin AN 5 supresses the formation of ulcers in all experimental models.?From the broad pharmacological studies of Gastrofensin AN 5 on this model it can be seen that even a dose of 0.100 mg/kg has a high antiulcer activity.?The increase of the dose leads to a regular increase of the antiulcer activity, the highest suppression of the ulcer index being reaches at a dose of 1 mg/kg (86.15%).?The comparative studies with Ranitidine and Cimetidine on the same experimental models of gastric ulcers show that Gastrofensin AN 5 possesses an antiulcer activity many times higher than that of the above-mentioned drugs.