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BLX3887
还可以产品编号 T37273Cas号 934758-70-0
BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.
BLX3887
还可以产品编号 T37273Cas号 934758-70-0
BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 500 μg | ¥ 560 | 35日内发货 | |
| 1 mg | ¥ 1,060 | 35日内发货 | |
| 5 mg | ¥ 4,250 | 35日内发货 | |
| 10 mg | ¥ 7,450 | 35日内发货 |
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| 产品描述 | BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro. |
| 分子量 | 308.52 |
| 分子式 | C10H5Cl3FN3O |
| CAS No. | 934758-70-0 |
| 密度 | 1.714 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | DMF: 30 mg/mL DMSO: 15 mg/mL DMSO:PBS (pH 7.2) (1:5): 0.16 mg/mL |
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