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5-hydroxy Omeprazole

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产品编号 T37659Cas号 92340-57-3

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

5-hydroxy Omeprazole

5-hydroxy Omeprazole

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产品编号 T37659Cas号 92340-57-3

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

规格	价格	库存	数量
500 μg	¥ 5,330	35日内发货
1 mg	¥ 8,500	35日内发货

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产品描述

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

化学信息

分子量	361.42
分子式	C₁₇H₁₉N₃O₄S
CAS No.	92340-57-3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

Ethanol: 2 mg/mL (5.53 mM), Sonication is recommended.

DMF: 20 mg/mL (55.34 mM), Sonication is recommended.

DMSO: 10 mg/mL (27.67 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	2.7669 mL	13.8343 mL	27.6686 mL	138.3432 mL
5 mM	0.5534 mL	2.7669 mL	5.5337 mL	27.6686 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
10 mM	0.2767 mL	1.3834 mL	2.7669 mL	13.8343 mL
20 mM	0.1383 mL	0.6917 mL	1.3834 mL	6.9172 mL

DMF

	1mg	5mg	10mg	50mg
50 mM	0.0553 mL	0.2767 mL	0.5534 mL	2.7669 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

TargetMol | Animal experiments

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2O TargetMol | reagent

TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

5-hydroxy Omeprazole5hydroxy Omeprazole5 hydroxy Omeprazole

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