EBOV-IN-5 (compound 14) serves as an antiviral agent targeting the Ebola virus (EBOV) by disrupting its entry mechanism into host cells. It specifically blocks the interaction between the EBOV glycoprotein EBOV-GPcl and the essential host receptor NPC1, which is crucial for the virus's fusion and entry into the cell. [7] [1]

EBOV-IN-5 (compound 14) 在 HeLa 细胞中的 CC50 为 30 μM，其对 Vero 细胞具有较低的细胞毒性，CC50 值超过 100 μM [1]。此外，50 μM 的 EBOV-IN-5 显著抑制了 EBOV-GPcl/NPC1 的相互作用，其对 pEBOV (EBOV-GP-假型病毒) 的 IC50 为 4.69 μM [1]。另外，EBOV-IN-5 对非洲猪瘟病毒 (ASFV) 的 IC50 为 35.17 μM [1]。