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Neuropeptide AF (cattle)是一种RFamide家族的酰胺化十八肽,主要作用于Mas相关基因受体A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR))和MrgprC11,其EC50分别约为60 nM和300 nM。此外,该化合物还能激活G蛋白偶联受体NPFF1 (Neuropeptide Y Receptor) 和NPFF2,EC50范围分别为25-325 nM和1-5 nM。Neuropeptide AF (cattle)具有显著的抗阿片及疼痛调节功能。
Neuropeptide AF (cattle)是一种RFamide家族的酰胺化十八肽,主要作用于Mas相关基因受体A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR))和MrgprC11,其EC50分别约为60 nM和300 nM。此外,该化合物还能激活G蛋白偶联受体NPFF1 (Neuropeptide Y Receptor) 和NPFF2,EC50范围分别为25-325 nM和1-5 nM。Neuropeptide AF (cattle)具有显著的抗阿片及疼痛调节功能。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Neuropeptide AF (cattle), an amidated octadecapeptide and RFamide neuropeptide, serves as a ligand for Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) with an EC50 of approximately 60 nM, and MrgprC11 with an EC50 of around 300 nM. It also activates G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) with an EC50 ranging from ~25 to 325 nM, and NPFF2 with an EC50 of approximately 1 to 5 nM. Furthermore, Neuropeptide AF (cattle) exhibits anti-opiate effects and modulates related pain [1] [2]. |
分子量 | 1920.13 |
分子式 | C89H130N24O24 |
CAS No. | 99588-52-0 |
存储 | keep away from moisture | Shipping with blue ice. |
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