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Anti-LILRB4 Monoclonal Antibody
产品编号 TMAZ-0181
别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3
Anti-LILRB4 Monoclonal Antibody is a rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody can be used in ELISA, FACS.
Anti-LILRB4 Monoclonal Antibody
Anti-LILRB4 Monoclonal Antibody
产品编号 TMAZ-0181 别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3
Anti-LILRB4 Monoclonal Antibody is a rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 876 | 7日内发货 | |
| 50 μg | ¥ 1,051 | 7日内发货 | |
| 100 μg | ¥ 1,471 | 7日内发货 |
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产品介绍
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偶联与修饰
抗原信息
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| 产品描述 | Anti-LILRB4 Monoclonal Antibody is a rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody can be used in ELISA, FACS. |
| 别名 | Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of LILRB4 overexpressed 351F cells with TMAZ-0181, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LILRB4 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed: 11875462). Receptor for FN1 (PubMed: 34089617). Receptor for apolipoprotein APOE (PubMed: 30333625). Receptor for ALCAM/CD166 (PubMed: 29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed: 9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed: 19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed: 34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed: 16493035, PubMed: 19833736, PubMed: 29263213). Induces up-regulation of CD86 on dendritic cells (PubMed: 19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed: 11875462) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 2 |
| 免疫原 | LILRB4 |
| 抗原种属 | Human |
| 基因ID | 11006 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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