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PF470 (PF-06297470) 作为一种mGluR5(代谢型谷氨酸受体5)的负变构调节剂,在帕金森病模型中显示出显著疗效。然而,由于在毒理学研究中发现了潜在问题,其临床开发被终止。
PF470 (PF-06297470) 作为一种mGluR5(代谢型谷氨酸受体5)的负变构调节剂,在帕金森病模型中显示出显著疗效。然而,由于在毒理学研究中发现了潜在问题,其临床开发被终止。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies. |
别名 | PF-06297470 |
分子量 | 332.36 |
分子式 | C18H16N6O |
CAS No. | 1539296-45-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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