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SAH (S-Adenosylhomocysteine) 属于氨基酸衍生物,是腺苷和半胱氨酸合成的中间体。SAH 是一种 METTL3-METTL14 异二聚体复合物的抑制剂 (IC50=0.9 µM)。SAH 是多种代谢途径中的调节剂。
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SAH (S-Adenosylhomocysteine) 属于氨基酸衍生物,是腺苷和半胱氨酸合成的中间体。SAH 是一种 METTL3-METTL14 异二聚体复合物的抑制剂 (IC50=0.9 µM)。SAH 是多种代谢途径中的调节剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 298 | 现货 | |
5 mg | ¥ 475 | 现货 | |
10 mg | ¥ 828 | 现货 | |
25 mg | ¥ 1,320 | 现货 | |
50 mg | ¥ 1,960 | 现货 | |
100 mg | ¥ 2,930 | 现货 | |
500 mg | ¥ 6,620 | 现货 |
产品描述 | SAH (S-Adenosylhomocysteine) belongs to the group of amino acid derivatives that are intermediates in the synthesis of adenosine and cysteine. SAH is an inhibitor of the METTL3-METTL14 heterodimeric complex (IC50=0.9 µM).SAH is a regulator of several metabolic pathways. |
靶点活性 | METTL3-METTL14:0.9 µM |
体外活性 | 方法:METTL3-14 复合物用 SAH (0-100 µM) 处理,使用 METTL3-14 Assay 检测抑制活性。 结果:SAH 对 METTL3-14 活性表现出强烈的抑制作用,IC50 值为 0.9±0.1 µM。[1] |
别名 | SAH (S-Adenosylhomocysteine), S-(5'-腺苷)-L-高半胱氨酸 |
分子量 | 384.41 |
分子式 | C14H20N6O5S |
CAS No. | 979-92-0 |
Smiles | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |
密度 | 1.91g/cm3 |
存储 | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (117.06 mM), Sonication is recommended. 10% DMSO+90% Saline: 12.5 mg/mL (32.52 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
10% DMSO+90% Saline/DMSO
DMSO
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