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PROTACSMARCA2 degrader-5 (Compound I-425) 作为一种PROTAC降解剂,专门针对SWI/SNF复合体中的催化亚基SMARCA2.该化合物在MV411和A549细胞系中有效降解SMARCA2,其DC50值小于100 nM;同时在MV411细胞系中也能降解SMARCA4,DC50值介于100-500 nM之间.
PROTACSMARCA2 degrader-5 (Compound I-425) 作为一种PROTAC降解剂,专门针对SWI/SNF复合体中的催化亚基SMARCA2.该化合物在MV411和A549细胞系中有效降解SMARCA2,其DC50值小于100 nM;同时在MV411细胞系中也能降解SMARCA4,DC50值介于100-500 nM之间.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PROTACSMARCA2 degrader-5 (Compound I-425) functions as a PROTAC degrader targeting the catalytic subunit SMARCA2 of the SWI/SNF complex. It effectively degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM, and also degrades SMARCA4 in MV411, exhibiting a DC50 ranging from 100-500 nM. |
分子量 | 1037.32 |
分子式 | C57H72N12O5S |
CAS No. | 2568277-68-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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