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Purine riboside-5'-O-triphosphate sodium 是 Nebularine (HY -103694) 的活性代谢产物,作为 DNA 引物酶 ATP 和 GTP 聚合活性的抑制剂,其IC50值分别为 35 µM 和 28 µM。此外,Purine riboside-5'-O-triphosphate sodium 还能抑制钙调素依赖性蛋白激酶II (calmodulin-dependent protein kinase II (CaMKII)),其Ki值为 590 µM。
Purine riboside-5'-O-triphosphate sodium 是 Nebularine (HY -103694) 的活性代谢产物,作为 DNA 引物酶 ATP 和 GTP 聚合活性的抑制剂,其IC50值分别为 35 µM 和 28 µM。此外,Purine riboside-5'-O-triphosphate sodium 还能抑制钙调素依赖性蛋白激酶II (calmodulin-dependent protein kinase II (CaMKII)),其Ki值为 590 µM。
产品描述 | Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY-103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM. |
别名 | PTP tetrasodium |
分子量 | 580.09 |
分子式 | C10H11N4Na4O13P3 |
CAS No. | 35892-95-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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