Gisadenafil besylate

Name: Gisadenafil besylate
Brand: TargetMol
SKU: T11400
Rating: 4.5 (1 reviews)

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产品编号 T11400Cas号 334827-98-4

别名 UK 369003-26

Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (cGMP), with an IC50 of 3.6 nM .

Gisadenafil besylate

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产品编号 T11400 别名 UK 369003-26Cas号 334827-98-4

Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (cGMP), with an IC50 of 3.6 nM .

规格	价格	库存
2 mg	¥ 1,710	5日内发货
25 mg	¥ 7,170	8-10周
50 mg	¥ 9,320	8-10周
100 mg	¥ 14,400	8-10周

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产品描述	Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor ,prevents degradation of cyclic guanosine monophosphate (cGMP), with an IC50 of 3.6 nM .
靶点活性	PDE5A:3.6 nM, PDE1A:9.1 μM
体外活性	The IC50 of Gisadenafil for PDE5A is 3.6 nM. In contrast, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in specificity.Since some PDE5 inhibitors can also interact with PDE1 isotypes found within the cerebral vasculature, the specificity of Gisadenafil for PDE5 is confirmed.?This is directly tested with recombinant PDE5A and PDE1A overexpressed in COS-7 cells.
体内活性	Gisadenafil also restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels.
别名	UK 369003-26