Powder: -20°C for 3 years | In solvent: -80°C for 1 years
P-CRESOL-d3 (METHYL-d3) 是 P-CRESOL 的氘代化合物。P-CRESOL 的 CAS 号为 106-44-5。p-Cresol 是一种部分亲脂性部分,在正常条件下与血浆蛋白(接近 100%)强烈结合。对甲酚通过结合代谢,主要是硫酸化和葡萄糖醛酸化,但未结合的对甲酚至少部分通过尿液去除。
产品描述 | P-CRESOL-d3 (METHYL-d3) is a deuterated compound of P-CRESOL. P-CRESOL has a CAS number of 106-44-5. p-Cresol (4-methylphenol) is a partially lipophilic moiety which strongly binds to plasma protein (close to 100%) under normal conditions. p-Cresol is metabolized through conjugation, mainly sulphation and glucuronization, but removal of the unconjugated p-cresol is, at least in part, via the urine. Therefore it is not surprising that this compound, together with several other phenoles, is retained when the kidneys fail. P-Cresol is an end-product of protein breakdown, and an increase of the nutritional protein load in healthy individuals results in enhanced generation and urinary excretion. The serum p-cresol concentration in uremic patients can be decreased by changing to a low-protein diet. p-Cresol is one of the metabolites of the amino acid tyrosine, and to a certain extent also of phenylalanine, which are converted to 4-hydroxyphenylacetic acid by intestinal bacteria, before being decarboxylated to p-cresol (putrefaction). |
分子量 | 111.16 |
分子式 | C7D3H5O |
CAS No. | 108561-00-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 years
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
P-CRESOL-d3 (METHYL-d3) 108561-00-8 Inhibitor inhibitor inhibit