Arotinolol

产品编号 T10371Cas号 68377-92-4

别名 阿罗洛尔

Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is an antihypertensive agent.

Arotinolol

产品编号 T10371别名 阿罗洛尔Cas号 68377-92-4

规格	价格	库存	数量
2 mg	¥ 565	5日内发货
100 mg	¥ 6,430	6-8周

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产品介绍

生物活性

产品描述	Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. It is an antihypertensive agent.
体外活性	Arotinolol shows its selectivity of β-adrenergic receptors, the result of Arotinolol for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. Arotinolol shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol displaces 125I-ICYP binding to 5HT1B-receptors (pKis: 7.97 and 8.16 for β1 and β2 adrenergic receptors) [2].
体内活性	Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse [1].
别名	阿罗洛尔

化学信息

分子量	371.54
分子式	C₁₅H₂₁N₃O₂S₃
CAS No.	68377-92-4

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (672.88 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6915 mL	13.4575 mL	26.9150 mL	134.5750 mL
5 mM	0.5383 mL	2.6915 mL	5.3830 mL	26.9150 mL
10 mM	0.2692 mL	1.3458 mL	2.6915 mL	13.4575 mL
20 mM	0.1346 mL	0.6729 mL	1.3458 mL	6.7288 mL
50 mM	0.0538 mL	0.2692 mL	0.5383 mL	2.6915 mL
100 mM	0.0269 mL	0.1346 mL	0.2692 mL	1.3458 mL