Spilanthol, an orally active compound with analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial, and insecticidal properties, facilitates the induction of cAMP, thereby inhibiting the negative regulation of the urinary concentration mechanism. It is also utilized in diuretic research [1] [4] [5].

Spilanthol（50~150 μM，24小时）不影响A549人肺上皮细胞的活性。[3]

Spilanthol（1-1.875 mg/kg，IP，一次）显示出在醋酸诱发的腹部扭动及辣椒素引起的舔爪行为的ICR雄性小鼠模型中的镇痛效果[2]。同一化合物，以30 mg/kg剂量口服，连续四天，对5-氟尿嘧啶引起的瑞士小鼠肠黏膜炎症模型中的肠损伤具有保护作用[4]。此外，Spilanthol在800 mg/kg剂量口服给药后，在C57BL/6J雄性成鼠中表现出利尿作用[5]。