2130
490
21
940
41
Cat. No. | Product Name | ||
---|---|---|---|
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L7850 | 高溶解性3D结构多样性片段化合物库 | 1079 compounds | |
高溶解性3D 结构多样性片段库包含1079 个化合物。 | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; | |||
L9240 | 农药化合物库 | 270 compounds | |
270种农药相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1380 | 转录因子库 | 695 compounds | |
695 种转录因子靶向、结构新颖的化合物; | |||
L4400 | 抗生素库 | 692 compounds | |
692 个具有抗菌活性化合物的独特集合,是医药研究的优良工具库和药物筛选的有效载体; | |||
L2400 | 内分泌激素分子库 | 784 compounds | |
784 种与内分泌系统相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L2100 | 抗癌化合物库 | 7234 compounds | |
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9600 | 多肽分子库 | 791 compounds | |
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究; | |||
L1310 | 细胞骨架化合物库 | 759 compounds | |
759 种细胞骨架相关的化合物,可以用于高通量和高内涵筛选; | |||
L5100 | 含氟化合物库 | 574 compounds | |
574 个含氟化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L6750 | 活血化瘀中药单体库 | 580 compounds | |
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。 | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L6820 | 烟草单体化合物库 | 747 compounds | |
747种烟草单体化合物的独特集合,可用于高通量筛选和高内涵筛选 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37603L |
Osteogenic Growth Peptide (10-14) acetate
Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base) |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Osteogenic Growth Peptide (10-14) acetate (Osteogenic Growth Peptide) 是一种 Src 抑制剂,是一种有效的有丝分裂原和促成骨和造血因子。Osteogenic Growth Peptide (10-14) acetate 负责与 OGP 受体结合并激活细胞内 Gi 蛋白激酶信号通路。 | |||
TP1820L |
Osteogenic Growth Peptide, OGP acetate
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) |
Others | Others |
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽,存在于血清中,浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。 | |||
T8679 |
Epidermal Growth Factor
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Epidermal Growth Factor 与表皮生长因子受体 (EGFR) 结合并刺激细胞生长和增殖。它被批准用于治疗糖尿病足溃疡。 | |||
TP1155L |
Human growth hormone-releasing factor acetate
|
GHSR | GPCR/G Protein |
Human growth hormone-releasing factor acetate 是一种下丘脑多肽,通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。 | |||
TP1155 |
Human growth hormone-releasing factor
Growth Hormone Releasing Factor human |
||
Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormo | |||
T37603 |
Osteogenic Growth Peptide (10-14)
|
||
YGFGG, C-terminal pentapeptide fragment of the osteogenic growth peptide (OGP), (H-8640), showed the full spectrum of OGP-like bioactivities. It has attracted considerable interest as bone anabolic agent and hematopoietic stimulator. | |||
TP1820 |
Osteogenic Growth Peptide, OGP
|
||
Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury | |||
T8680 |
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
|
||
FIBROBLAST GROWTH FACTOR, BASIC, HUMAN 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T8680,CAS号为 62031-54-3。 | |||
TP1122L |
IGF-I 30-41 acetate(82177-09-1 free base)
Insulin-like Growth Factor I (30-41) acetate |
Others | Others |
IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) 是胰岛素样生长因子 I (IGF-I) 的氨基酸 30 至 41 片段。 | |||
T37595 |
Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)
|
||
Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF. Brain-derived aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. aFGF (1-11) corresponds to amino acid residues 1-11 of the full length peptide. | |||
T37819 |
Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)
|
||
Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength pept... | |||
T21723L |
EGF Receptor Peptide Acetate
EGF Receptor Peptide Acetate (96249-43-3 Free base),Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) |
Others | Others |
Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate (96249-43-3 Free base)) 存在于细胞表面,通过与其特异性配体的结合而被激活。EGFR 属于受体酪氨酸激酶(RTK) 的 ErbB 家族。 | |||
T37820 |
Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
|
||
Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide. | |||
TP2229 |
Epidermal growth factor receptor (994-1002) acetyl/amide
|
Others | Others |
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands. | |||
T76539 |
Insulin-like growth factor II
|
Others | Others |
Insulin-like growth factor II (IGF-2)为人血清中主要生长激素,对神经突生长具有许可性和直接作用,同时增强交感与感觉神经元的生存能力。 | |||
T75713 |
Human growth hormone-releasing factor TFA
|
||
Growth Hormone Releasing Factor human TFA 是下丘脑多肽,通过与GHRHR结合,刺激生长激素生成和释放。 | |||
T76321 |
Brain Derived Basic Fibroblast Growth Factor (1-24)
|
||
Brain Derived BasicFibroblast Growth Factor(1-24) (FGF basic 1-24) 是一种合成肽,表现出抗细菌和抗HBV 的活性。Brain Derived BasicFibroblast Growth Factor(1-24) 可用于感染性疾病和免疫性疾病的研究。 | |||
T6996 |
SU 5402
SU5402 |
VEGFR; FGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU 5402 是多靶点受体酪氨酸激酶抑制剂,能够抑制VEGFR2 (IC50:20 nM),FGFR1 (IC50:30 nM),PDGFRβ (IC50:510 nM)。 | |||
T5466 |
Tyrosine kinase-IN-1
|
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。 | |||
T9030 |
SU4984
|
FGFR; IGF-1R; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU4984 是蛋白质酪氨酸激酶抑制剂,能够抑制成纤维细胞生长因子受体 1 (FGFR1) (IC50:10-20 μM),还能够抑制血小板衍生的生长因子受体和胰岛素受体的活性。它可用于研究癌症。 | |||
T34684 |
Somatotropin (6-13)
Human growth hormone (6-13) |
Others | Others |
Somatotropin (6-13) is a growth hormone. | |||
T82322 |
GHRF, mouse
Mouse growth hormone-releasing factor |
||
GHRF, mouse为含44个氨基酸的小鼠生长激素释放肽,能够促进生长激素的释放与合成。 | |||
T2642 |
PD173074
|
Apoptosis; EGFR; VEGFR; FGFR; IGF-1R; Src | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD173074 是一种 FGFR1抑制剂,IC50为 25 nM。它也可抑制 VEGFR2活性,IC50值为 100-200 nM。 | |||
T5475 |
ZD-4190
|
EGFR; VEGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
ZD-4190 是血管内皮细胞生长因子受体 2 (VEGFR2) 和表皮生长因子受体 (EGFR) 信号传导的抑制剂,用于治疗癌症。 | |||
T1777 |
Nintedanib
BIBF 1120,Intedanib,尼达尼布 |
VEGFR; FGFR; FLT; PDGFR; Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Nintedanib (Intedanib) 是一种三重血管激酶抑制剂,抑制 VEGFR1、VEGFR2、VEGFR3 (IC50=34/13/13 nM),FGFR1、FGFR2、FGFR3 (IC50=69/37/108 nM),PDGFRα、PDGFRβ (IC50=59/65 nM)。Nintedanib 具有抗肿瘤活性,通过抑制血管生成来抑制肿瘤生长。 | |||
T23127 |
PD-161570
PD 161570 |
EGFR; FGFR; PDGFR; Src | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂,IC50 为 39.9 nM,Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化,IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶,IC50 值分别为 310、240 和 44 nM。 | |||
T0097L |
Pazopanib
帕唑帕尼,GW786034 |
VEGFR; FGFR; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Pazopanib (GW786034) 是一种小分子抑制剂,可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。 | |||
T3466 |
FIIN-3
|
EGFR; FGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
FIIN-3 是FGFR 的不可逆抑制剂,对FGFR1、FGFR2、FGFR3和FGFR4的IC50值分别为13.1、21、31.4和35.3 nM。 | |||
T16975 |
TAK-593
|
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
TAK-593 是一种 VEGFR2 和 PDGFR 抑制剂,能够作用于VEGFR1 (IC50:3.2 nM)、VEGFR2 (IC50:0.95 nM)、VEGFR3 (IC50:1.1 nM)、PDFGRα (IC50:4.3 nM)、PDFGRβ (IC50:13 nM)。 | |||
T2358 |
ENMD-2076
|
Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
ENMD2076是一种多靶点激酶抑制剂,抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。 | |||
TP2364 |
Acetyl tetrapeptide-3
Kollaren 6,Uxi hair growth peptide,Folixyl |
||
Acetyl tetrapeptide-3 is a bioactive chemical. | |||
T8976 |
PD-089828
|
EGFR; FGFR; PDGFR; Src | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD-089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂,IC50分别为0.15、1.76 和 5.47 µM。它也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂,IC50 为 0.18 µM。 | |||
T7945 |
SU14813
|
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
SU14813 是一种多靶点受体酪氨酸激酶抑制剂,能够抑制 VEGFR2 (IC50:50 nM),VEGFR1 (IC50:2 nM),PDGFRβ (IC50:4 nM),KIT (IC50:15 nM)。 | |||
T0520 |
Lenvatinib
仑伐替尼,E7080 |
VEGFR; FGFR; c-RET; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等,具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。 | |||
T2372 |
Ponatinib
帕纳替尼,AP24534,普纳替尼 |
VEGFR; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Ponatinib (AP24534) 是一种有多靶点激酶抑制剂,具有口服活性,可以抑制 Abl、PDGFRα、VEGFR2、FGFR1 和 Src (IC50=0.37/1.1/1.5/2.2/5.4 nM)。Ponatinib 具有抗肿瘤活性,可以用于治疗成人慢性粒细胞白血病。 | |||
T4425 |
JK-P3
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
JK-P3 是广谱 VEGFR2抑制剂。它能够抑制 VEGF-A 刺激的 VEGFR2 激活和细胞内信号转导,也可阻碍内皮单层细胞迁移和血管生成,影响成纤维细胞生长因子受体激酶在体外的活性。它具有抗血管生成的作用。 | |||
TQ0317 |
R1530
R-1530,R 1530 |
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
R1530 是一种多激酶抑制剂,具有抗肿瘤和抗血管生成活性。它是具有口服活性的有丝分裂/血管生成高效双重作用抑制剂, 抑制 VGFR2、FGFR1作用的 IC50分别为 10 nM 和 28 nM。 | |||
T7611 |
ODM-203
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ODM-203 是 FGFR 和 VEGFR 家族的抑制剂,具有显著的抗肿瘤活性,能够诱导抗肿瘤免疫。 | |||
T15185 |
Lucitanib
E-3810,德立替尼 |
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Lucitanib (E-3810) 是 VEGFR 和 FGFR 的双重抑制剂,有效和选择性地抑制VEGFR1 (IC50:7 nM),VEGFR2 (IC50:25 nM),VEGFR3 (IC50:10 nM),FGFR1 (IC50:17.5 nM),FGFR2 (IC50:82.5 nM)。 | |||
T9625 |
Sandalore
|
Apoptosis | Apoptosis |
Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。 | |||
T9460 |
iMDK
|
PI3K | PI3K/Akt/mTOR signaling |
iMDK 是PI3K 抑制剂,能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌,而不会伤害正常细胞和小鼠。 | |||
TP1121 |
IGF-I (30-41) TFA(82177-09-1,FREE)
Insulin-like Growth Factor I (30-41) (TFA) |
||
IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). | |||
T6082 |
SSR128129E
SSR |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SSR128129E (SSR) 是一种变构和口服活性 FGFR1 抑制剂 (IC50:1.9 μM),但不影响其他相关的 RTK。 | |||
T6166 |
Telatinib
Bay 57-9352,替拉替尼 |
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Telatinib (Bay 57-9352) 是一种口服具有活力的,小分子的 VEGFR2,VEGFR3,PDGFα 和 c-Kit 抑制剂,它们的 IC50 值分别为6,4,15,1 nM。 | |||
TP1122 |
IGF-I (30-41)
Insulin-like Growth Factor I (30-41),IGF-I 30-41 |
||
IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). | |||
TP1124 |
IGF-I (24-41)
Insulin-like Growth Factor I (24-41),IGF-I 24-41 |
||
IGF-I (24-41) is a 24-41 amino acid fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective | |||
T6184 |
Orantinib
SU6668,TSU-68,NSC 702827 |
Apoptosis; VEGFR; FGFR; PDGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Orantinib (NSC 702827) 是一种多靶点受体酪氨酸激酶抑制剂,对 Flt-1、PDGFRβ和FGFR1的Ki 值分别为 2.1 μM、8 nM 和 1.2 μM。 | |||
T8541 |
Lenvatinib mesylate
仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼 |
VEGFR; FGFR; c-RET; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Lenvatinib mesylate (E7080 (mesylate)) 是一种口服具有活力的,多靶点酪氨酸激酶抑制剂,能够抑制血管内皮生长因子受体(VEGFR1-3),成纤维细胞生长因子受体(FGFR1-4),干细胞因子受体(KIT),血小板衍生生长因子受体(PDGFR),转染期间重排(RET),具有效抗癌作用。 | |||
T8496 |
MAZ51
|
Apoptosis; VEGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。 | |||
T5637 |
Triflumuron
|
Others | Others |
Triflumuron 是一种杀虫剂,属于所谓的昆虫生长调节剂。它抑制昆虫幼虫合成甲壳素,导致死亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8213 |
Isolinderalactone
|
NOS; STAT | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Isolinderalactone 具有抗炎和抗癌能力,具有中等的 iNOS 抑制活性,IC50 值为 0.30 uM。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T2734 |
Sennoside B
番泻苷 B,番泻苷B |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Sennoside B 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷。它可通过与 PDGF-BB 及其受体结合并下调 PDGFR-β 信号传导途径来抑制 PDGF 刺激的细胞增殖。 | |||
TN2081 |
Maohuoside A
|
MAPK | MAPK |
Maohuoside A 是从 E. koreanum 中分离出的单一化合物,具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ,促进骨髓间充质干细胞的成骨作用。 | |||
T4A2456 |
Gamabufotalin
Gamabufagin,日本蟾蜍毒苷元 |
COX | Immunology/Inflammation; Neuroscience |
Gamabufotalin (Gamabufagin) 是一种蟾蜍甾烯,存在于蟾酥中。它稳定性高,毒性低,被广泛用于癌症的研究。 | |||
T17280 |
(Z)-Guggulsterone
|
Apoptosis; VEGFR; Akt | Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul 的成分,可通过引起细胞凋亡来抑制人前列腺癌细胞的生长,还可通过抑制VEGF-VEGF-R2-Akt 信号传导轴来抑制血管生成。 | |||
T22974 |
Methyl 2,5-dihydroxycinnamate
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Methyl 2,5-dihydroxycinnamate 是 erbstatin 类似物,是一种高效、稳定的 EGF 受体相关酪氨酸激酶的抑制剂。 | |||
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物,具有抑制PTK 的作用, 对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用,可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。 | |||
T10388 |
Asparagusic acid
1,2-二噻戊环-4-羧酸,芦笋酸 |
Parasite | Microbiology/Virology |
Asparagusic acid 是芦笋植物中的一种含硫气味成分,是植物生长抑制剂,具有抗寄生虫作用。 | |||
T3870 |
Cyasterone
杯苋甾酮,Cyasteron |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Cyasterone (Cyasteron) 是主要分离自金疮小草的一种天然 EGFR 抑制剂。它通过诱导细胞凋亡和细胞周期阻滞表现出抗增殖作用,可用于抗人类肿瘤的相关研究。 | |||
T1431 |
Khellin
凯林,Amicardine,Methafrone,Visammin |
EGFR; Others | Angiogenesis; JAK/STAT signaling; Others; Tyrosine Kinase/Adaptors |
Khellin (Methafrone) 是从阿米芹中提取得到的一种呋喃并色酮,是EGFR 抑制剂,IC50为 0.15 µM。它体外具有抗增殖活性,还具有抗痉挛和冠状动脉舒张作用。 | |||
T5061 |
Lumichrome
7,8-Dimethylalloxazine,光色素 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Lumichrome 是人类体内的内源性化合物,由核黄素光降解产生。它利用p53 依赖机制抑制人肺癌细胞生长并诱导凋亡。 | |||
T19355 |
Heparan Sulfate
硫酸乙酰肝素,硫酸类肝素 |
FGFR; Wnt/beta-catenin; Endogenous Metabolite | Angiogenesis; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞外基质和细胞表面表达丰富。 | |||
T1160 |
Fusidic acid
Fusidine,夫西地酸 |
Others; CAT; Antibacterial; Antibiotic | Microbiology/Virology; Others; oxidation-reduction |
Fusidic acid (Fusidine) 是一种从 Fusidium coccineum 发酵液中分离出来的甾体类抗生素。它通过阻止核糖体释放翻译延长因子 G 来抑制细菌的生长。 | |||
TN1969 |
N-(p-Coumaroyl) serotonin
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚,具有抗氧化、抗动脉粥样硬化和抗炎作用,常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。 | |||
TN2132 |
Quinizarin
1,4-Dihydroxyanthraquinone,1,4-二羟基蒽醌 |
Others; DNA/RNA Synthesis; Antifungal | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Quinizarin (1,4-Dihydroxyanthraquinone) 是一种杀菌剂和杀虫剂,可抑制肿瘤细胞生长。 | |||
TN1727 |
Helichrysetin
4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。 | |||
TL0016 |
Sulforaphene
油菜 |
Apoptosis; ERK; EGFR; NF-κB | Angiogenesis; Apoptosis; JAK/STAT signaling; MAPK; NF-κB; Tyrosine Kinase/Adaptors |
Sulforaphene 是从萝卜种子中分离出来的天然产物,对鹿茸幼苗的 ED50 约为 2 x 10 -4 M。它通过抑制 EGFR、p-ERK1/2、NF-κB 和其他信号促进癌细胞凋亡并抑制迁移。 | |||
T2215 |
Ferulic Acid
Coniferic acid,Fumalic Acid,阿魏酸 |
FGFR; Endogenous Metabolite | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Ferulic Acid (Coniferic acid) 是新型的成纤维细胞生长因子受体 1 (FGFR1)抑制剂, 在FGFR1和FGFR2的IC50分别为 3.78 和 12.5 μM。 | |||
T8283 |
(+)-Bornyl Acetate
Bornyl acetate,1-乙酸冰片酯,(+)-乙酸龙脑酯 |
Others | Others |
(+)-Bornyl acetate 存在于 Pichtae 精油 (西伯利亚冷杉针油) 中。它能够显著抑制拟南芥幼苗根系生长。 | |||
T5S0384 |
Rhapontin
Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside |
Apoptosis; Others | Apoptosis; Others |
Rhapontin (Ponticin) 是药用大黄的一种成分,可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性,改善血糖和血脂,表明其具有显着的降糖作用,有望成为治疗2型糖尿病及其并发症的新药。 | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T3719 |
Daminozide
Succinic Acid,DMASA,Aminozide,丁酰肼 |
Histone Demethylase | Chromatin/Epigenetic |
Daminozide (Succinic Acid) 是一种植物生长调节剂,选择性地抑制 KDM2/7 JmjC 亚家族,对PHF8、KDM2A 和KIAA1718的IC50值分别为 0.55、1.5 和 2.1 μM。 | |||
T2754 |
Oxymatrine
Oxysophoridine,氧化苦参碱,Matrine N-oxide |
Influenza Virus; Autophagy; TGF-beta/Smad | Autophagy; Microbiology/Virology; Stem Cells |
Oxymatrine (Oxysophoridine) 是来自槐属物种根部的一种生物碱,具有抗炎,抗纤维化和抗肿瘤的作用。它是一种用于治疗乙型肝炎病毒的中药。它可抑制博卡病毒 MVC 复制,降低病毒基因表达并减少病毒感染诱导的细胞凋亡。它还可以抑制 iNOS 的表达和 TGF-β/Smad 通路。 | |||
T2906 |
Tanshinone IIA
丹参酮IIA,Tanshinone B,Dan Shen ketone |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tanshinone IIA (Tanshinone B) 是红根丹参根系中的一种主要组合物。它能够利用靶向 VEGF/VEGFR2的蛋白激酶结构域,抑制血管生成。 | |||
T3912 |
Saikosaponin B1
柴胡皂苷B1,柴胡皂苷 B1 |
Others | Others |
Saikosaponin B1 是柴胡的生物活性成分,具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤模型中的肿瘤生长。 | |||
T1737 |
Genistein
NPI 031L,三叶草,染料木素,金雀异黄酮 |
Apoptosis; EGFR; Endogenous Metabolite; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors |
Genistein (NPI 031L) 是一种大豆异黄酮,是一种多重的酪氨酸激酶抑制剂,通过改变细胞凋亡,细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。 | |||
T2995 |
Chrysophanol
大黄酚,3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Chrysophanol (Turkey Rhubarb) 是掌叶大黄中的一种蒽醌类天然产物,可抑制EGF-诱导的EGFR 磷酸化,且抑制AKT 和mTOR/p70S6K 激活。 | |||
T13741 |
Isoviolanthin
异佛莱心苷,异佛来心苷 |
Others | Others |
Isoviolanthin 是一种黄酮类苷类化合物,提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力,对正常细胞没有毒性影响,对转移性肝癌晚期具有潜在的研究价值。 | |||
T0724 |
Formononetin
Biochanin B,Flavosil,刺芒柄花素,Formononetol |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Formononetin (Flavosil) 是一种 FGFR2抑制剂,IC50约为4.31 μM。 它是一种 O-甲基化的异黄酮,是来自黄芪根的植物雌激素,可有效抑制血管生成和肿瘤生长。 | |||
T6427 |
Butein
2’,3,4,4’-tetrahydroxy Chalcone,紫铆因 |
Apoptosis; EGFR; Others; PDE; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors |
Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂,也是蛋白酪氨酸激酶抑制剂,还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路,靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。 | |||
T8846 |
beta-Escin
B-escin,AESCINE,beta-七叶素 |
Immunology/Inflammation related | Immunology/Inflammation |
beta-Escin 是七叶树种子的主要活性成分。它可抑制碱性成纤维细胞生长因子所诱导的增殖、迁移、管形成以及体内 CAM 血管生成。它具有研究抗血管生成作用的分子机制的潜力。 | |||
T1181 |
Gefitinib
ZD1839,吉非替尼 |
EGFR; Tyrosine Kinases; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Gefitinib (ZD1839) 是一种 EGFR 一代抑制剂,具有口服活性,抑制 EGFR 19 Del 和 L858R 突变。Gefitinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。Gefitinib 用药会产生 EGFR C797S 耐药突变。 | |||
T2896 |
Alantolactone
土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor |
Apoptosis; STAT; TGF-beta/Smad | Apoptosis; JAK/STAT signaling; Stem Cells |
Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T20945 |
2,4-D
Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 | |||
T1289 |
Fusidic acid sodium salt
Sodium fusidate,夫西地酸钠,Fusidate Sodium,Fucidin,SQ-16360 |
Others; CAT; Antibacterial; Antibiotic | Microbiology/Virology; Others; oxidation-reduction |
Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。 | |||
TN2354 |
Methylnissolin
3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷 |
ERK; PDGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
Methylnissolin 是从黄芪中分离的一种天然产物,可抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖,IC50为 10 μM。。它通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化,具有抗菌和抗癌作用。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T6485 |
Embelin
NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid |
Apoptosis; NF-κB; Lipoxygenase; IAP; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB |
Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂,诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路,从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长,诱导凋亡,并激活 caspase-9。 | |||
TMO2790 |
1-Naphthaleneacetic acid
Transplantone,1-Naphthylacetic acid,α-Naphthaleneacetic acid,Phyomone,1-萘乙酸 |
Phospholipase | Metabolism |
1-Naphthaleneacetic acid (Transplantone) 是一种 PLA2抑制剂,IC50=13.16 μM。它也是一种合成的植物生长素,可以促进植物生长。 | |||
T1152 |
Albendazole
SKF-62979,阿苯达唑 |
HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Albendazole (SKF-62979) 是一种广谱抗寄生虫剂,具有高效,低宿主毒性的特点。 它用于研究人类和动物的胃肠道寄生虫。 | |||
T3764 |
1-Triacontanol
Myricyl alcohol,1-Triacontanol,三十烷醇,Melissyl alcohol,Well-Bloom,Miraculan,Lithospermoside,triacontan-1-ol |
Others | Others |
1-Triacontanol (Melissyl alcohol) 是天然存在的植物生长调节剂。它是饱和长链醇,能够促进许多植物的生长。 | |||
TN2019 |
Orobol
3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮 |
BCL; Caspase; PI3K | Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K,对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。 | |||
T2857 |
2,5-Dihydroxybenzoic acid
龙胆酸,5-Hydroxysalicylic acid,Gentisic acid,Phloretate,Carboxyhydroquinone,Hydroquinonecarboxylic acid,Gentianic acid |
FGFR; Others; Endogenous Metabolite | Angiogenesis; Metabolism; Others; Tyrosine Kinase/Adaptors |
2,5-Dihydroxybenzoic acid (Gentisic acid) 是一种苯甲酸的代谢物,也是一种纤维母细胞生长因子(fibroblast growth factor)的强效抑制剂。 | |||
T13108 |
Pamufetinib
H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂,能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。 | |||
T1205 |
Chloramphenicol
Chlornitromycin,Levomycetin,Chloromycetin,氯霉素 |
ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。 | |||
T3025 |
Asiaticoside
BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,积雪草皂苷,NSC166062,积雪草苷 |
Apoptosis; p38 MAPK; Reactive Oxygen Species; Endogenous Metabolite; TGF-beta/Smad | Apoptosis; Immunology/Inflammation; MAPK; Metabolism; NF-κB; Stem Cells |
Asiaticoside (Emdecassol) 是一种从积雪草中分离得到的三萜皂苷化合物,具有抗氧化、抗炎、抗溃疡等作用。在瘢痕疙瘩成纤维细胞中,它通过活化 Smad7,抑制 TGF-βRI 和 TGF-βRII,抑制 TGF-β/Smad 信号通路。 | |||
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Cat. No. | Product Name | Species | Expression System |
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TMPJ-00795 |
Growth Hormone Protein, Mouse, Recombinant
Gh1,Somatotropin,Gh,Growth Hormone |
Mouse | E. coli |
Somatotropin(GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. | |||
TMPY-04281 |
GHR/Growth Hormone R Protein, Rat, Recombinant (hFc)
growth hormone receptor |
Rat | HEK293 Cells |
GHR/Growth Hormone R Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55.4 kDa and the accession number is P16310-1. | |||
TMPY-02007 |
GHR/Growth Hormone R Protein, Rat, Recombinant (His)
growth hormone receptor |
Rat | HEK293 Cells |
GHR/Growth Hormone R Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.6 kDa and the accession number is P16310-1. | |||
TMPY-00394 |
Growth Hormone Protein, Human, Recombinant
GHB5,GH-N,GH1,IGHD1B,hGH-N,GHN,Growth hormone 1,GH |
Human | E. coli |
Growth Hormone Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.1 kDa and the accession number is P01241. | |||
TMPY-01448 |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His)
GHR/BP,growth hormone receptor,GHBP |
Mouse | HEK293 Cells |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.3 kDa and the accession number is Q3UP14. | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPY-04818 |
EGFR Protein, Cynomolgus, Recombinant (His)
epidermal growth factor receptor |
Cynomolgus | HEK293 Cells |
EGFR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is A0A2K5WK39. | |||
TMPJ-00356 |
GHR/Growth Hormone R Protein, Mouse, Recombinant (hFc)
GHBP,GHR,Somatotropin receptor,growth hormone recep... |
Mouse | HEK293 Cells |
Growth hormone receptor is a transmembrane receptor for growth hormone (GH). GH is a single-chain polypeptide that is mainly synthesized and released from the anterior pituitary gland and plays essential roles in growth, development and metabolism. GH exerts its physiological actions via GH binding to its receptor in its extracellular domain. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway lead... | |||
TMPY-00195 |
Growth Hormone Protein, Human, Recombinant (His)
GH-N,GHN,hGH-N,GH1,IGHD1B,GHB5,GH,growth hormone 1 |
Human | E. coli |
Growth Hormone Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 24.7 kDa and the accession number is P01241. | |||
TMPY-00977 |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc)
growth hormone receptor,GHR/BP,GHBP |
Mouse | HEK293 Cells |
GHR/Growth Hormone R Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is Q3UP14. | |||
TMPJ-00037 |
FGF-2 Protein, Mouse, Recombinant
Fibroblast Growth Factor 2,bFGF,HBGF-2,Basic Fibrob... |
Mouse | E. coli |
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari... | |||
TMPY-03156 |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His)
vascular endothelial growth factor C |
Mouse,Rat | HEK293 Cells |
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.5 kDa and the accession number is P97953-1. | |||
TMPY-01089 |
FGF-1 Protein, Mouse, Rat, Recombinant
fibroblast growth factor 1 (acidic) |
Mouse,Rat | E. coli |
FGF-1 Protein, Mouse, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is P61148. | |||
TMPY-01008 |
VEGFD Protein, Human, Recombinant (His)
VEGFD,c-fos induced growth factor (vascular endothe... |
Human | HEK293 Cells |
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915. | |||
TMPJ-00842 |
FGF-2 Protein, Rat, Recombinant
bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblas... |
Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g... | |||
TMPY-02638 |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
transforming growth factor, beta 1,转化生长因子,transform... |
Human,Rhesus,Cynomolgus,Canine | CHO Cells |
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2. | |||
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPY-01061 |
FGF-10 Protein, Human, Recombinant
fibroblast growth factor 10,KGF2 |
Human | E. coli |
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla... | |||
TMPY-03945 |
Latent TGF beta 1 Protein, Rat, Recombinant (His)
TGF β1,transforming growth factor, β1,transforming ... |
Rat | HEK293 Cells |
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246. | |||
TMPY-04830 |
GAS6 Protein, Mouse, Recombinant (His)
growth arrest-specific 6,Gas-6 |
Mouse | HEK293 Cells |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor... | |||
TMPY-04211 |
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
transforming growth factor, β1,TGF β1,transforming ... |
Cynomolgus | HEK293 Cells |
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa. | |||
TMPY-00608 |
TGF beta 1 Protein, Rat/Mouse, Recombinant
transforming growth factor, beta 1,transforming |
Mouse,Rat | HEK293 Cells |
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa. | |||
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPY-03466 |
PLGF/PGF Protein, Mouse, Recombinant
placental growth factor,Plgf,PIGF,AI854365 |
Mouse | HEK293 Cells |
PLGF/PGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.6 kDa and the accession number is P49764. | |||
TMPY-03958 |
TGF alpha Protein, Human, Recombinant
transforming growth factor α,转化生长因子,transforming |
Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (... | |||
TMPY-05206 |
IGFBP-5 Protein, Human, Recombinant (His)
insulin-like growth factor binding protein 5,IBP5 |
Human | Baculovirus Insect Cells |
IGFBP-5 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 30 kDa and the accession number is P24593. | |||
TMPY-03382 |
FGF-6 Protein, Human, Recombinant
HBGF-6,HST2,fibroblast growth factor 6 |
Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d... | |||
TMPJ-00090 |
FGF-9 Protein, Human, Recombinant
Fibroblast Growth Factor 9,Heparin-Binding Grow... |
Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial c... | |||
TMPJ-01469 |
NGF Protein, Human, Recombinant (E. colli)
NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Ne... |
Mouse | E. coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo... | |||
TMPY-02626 |
FGF-18 Protein, Human, Recombinant (His)
FGF-18,ZFGF5,fibroblast growth factor 18 |
Human | HEK293 Cells |
FGF-18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.3 kDa and the accession number is O76093. | |||
TMPJ-01011 |
FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-act... |
Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... | |||
TMPY-01413 |
Cripto Protein, Human, Recombinant (His)
CR,CRIPTO,teratocarcinoma-derived growth factor 1,C... |
Human | HEK293 Cells |
Cripto Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is AAH22393.1. | |||
TMPY-02118 |
IGFBP-6 Protein, Mouse, Recombinant (His)
IGFBP-6,insulin-like growth factor binding protein ... |
Mouse | HEK293 Cells |
IGFBP-6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P47880. | |||
TMPY-06984 |
EGF Protein, Mouse, Recombinant (Yeast)
表皮生长因子,AI790464,epidermal growth factor |
Mouse | P. pastoris (Yeast) |
EGF Protein, Mouse, Recombinant (Yeast) is expressed in yeast. The predicted molecular weight is 6 KDa. and the accession number is P01132. | |||
TMPY-00210 |
FGF-2 Protein, Mouse, Recombinant (His)
Fgfb,bFGF,Fgf-2,fibroblast growth factor 2 (basic) |
Mouse | E. coli |
FGF-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P15655. | |||
TMPY-02112 |
FGFR4 Protein, Human, Recombinant (His)
TKF,JTK2,CD334,fibroblast growth factor receptor 4 |
Human | HEK293 Cells |
FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1. | |||
TMPY-03698 |
VEGF121b Protein, Human, Recombinant
MVCD1,VEGF,VPF,vascular endothelial growth factor A |
Human | HEK293 Cells |
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9. | |||
TMPY-01062 |
EGF Protein, Human, Recombinant (hFc)
Epidermal Growth Factor,表皮生长因子,URG,HOMG4 |
Human | HEK293 Cells |
EGF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33 kDa and the accession number is P01133-1. | |||
TMPJ-00254 |
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Latency-associated peptide,TGF-beta-3,Transforming growt... |
Human,Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regu... | |||
TMPY-01560 |
EGF Protein, Human, Recombinant
URG,epidermal growth factor,表皮生长因子,HOMG4 |
Human | E. coli |
EGF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 6.35 kDa and the accession number is P01133-1. | |||
TMPY-00500 |
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
transforming growth factor, beta 1,TGF β1,Tgfb-1,TG... |
Mouse | HEK293 Cells |
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202. | |||
TMPJ-00258 |
TGF beta 2 Protein, Human, Recombinant
Glioblastoma-derived T-cell suppressor factor,TGF-β-2,Transf... |
Human | HEK293 Cells |
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be... | |||
TMPY-02432 |
VEGF164 Protein, Rat, Recombinant
血管内皮生长因子,vascular endothelial growth factor A |
Rat | Baculovirus Insect Cells |
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2. | |||
TMPY-04911 |
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
vascular endothelial growth factor A,血管内皮生长因子 |
Human,Cynomolgus | HEK293 Cells |
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4. | |||
TMPY-04508 |
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
insulin-like growth factor binding protein 7,Mac25,... |
Mouse | HEK293 Cells |
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is A0A5E1. | |||
TMPY-01010 |
NGF Protein, Human, Recombinant
Beta-NGF,神经生长因子,β-NGF,NGFB,nerve growth factor (β p... |
Human | CHO Cells |
NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138. | |||
TMPY-01139 |
PDGFRA Protein, Human, Recombinant (His)
PDGFR-2,CD140A,RHEPDGFRA,platelet-derived growth fa... |
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1. | |||
TMPJ-01464 |
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Factor,IL-2,Interleu... |
Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... | |||
TMPY-03104 |
FGF-17 Protein, Human, Recombinant
fibroblast growth factor 17,HH20,FGF-13,FGF-17 |
Human | E. coli |
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-13 is preferentially expressed in the embryonic brain. It interacts with FGFR3 and FGFR4. FGF-13 plays an important role in the regulation of embryonic development and as signaling mol... | |||
TMPY-02327 |
HGF Protein, Human, Recombinant
SF,hepatocyte growth factor (hepapoietin A,HGFB,F-T... |
Human | CHO Cells |
HGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 79.7 kDa and the accession number is P14210-1. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0374 |
L-Leucine-d3
|
||
L-Leucine-d3 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。 | |||
TMIJ-0483 |
Phenmedipham-d3
|
||
Phenmedipham-d3 是 Phenmedipham 的氘代化合物。Phenmedipham 的 CAS 号为 13684-63-4。Phenmedipham 是一种除草剂,常用于甜菜和草莓的生长。 | |||
TMIH-0124 |
Brivanib Alaninate-d4
|
||
Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐,IC50值为 25 nM,具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制,对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。 | |||
TMIJ-0081 |
L-Leucine-d10
|
||
L-Leucine-d10 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。 | |||
TMID-0303 |
Vitamin A-d4
Retinol-d4 |
||
Vitamin A-d4 是 Vitamin A 的氘代化合物。Vitamin A 的 CAS 号为 68-26-8。Retinol 及其衍生物,在视网膜的代谢功能、上皮组织的生长和分化、骨骼的生长、生殖和免疫反应中起重要作用。膳食维生素 A 来源于植物中发现的多种类胡萝卜素。它富含肝脏、蛋黄和乳制品的脂肪成分。 | |||
TMID-0239 |
Forchlorfenuron-d5
|
||
Forchlorfenuron-d5 是 Forchlorfenuron 的氘代化合物。Forchlorfenuron 的 CAS 号为 68157-60-8。Forchlorfenuron 是一种植物生长调节剂和细胞分裂素,能够增加水果的果实大小,如猕猴桃和葡萄。 | |||
TMIJ-0457 |
Daminozide-d6 (dimethyl-d6)
|
||
Daminozide-d6 (dimethyl-d6) 是 Daminozide 的氘代化合物。Daminozide 的 CAS 号为 1596-84-5。Daminozide 是一种植物生长调节剂,选择性地抑制 KDM2/7 JmjC 亚家族,对PHF8、KDM2A和KIAA1718的IC50值分别为 0.55、1.5 和 2.1 μM。 | |||
T69995 |
Chlorhexidine-d8 HCl
|
||
Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC... | |||
TMIJ-0373 |
Biotin-d2
|
||
Biotin-d2 是 Biotin 的氘代化合物。Biotin 的 CAS 号为 58-85-5。Biotin 是一种水溶性B族维生素,是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢所必需的。 | |||
TMID-0121 |
DL-Homocysteine-3,3,4,4-d4
|
||
DL-Homocysteine-3,3,4,4-d4 是 DL-Homocysteine 的氘代化合物。DL-Homocysteine 的 CAS 号为 454-29-5。DL-Homocysteine 是弱神经毒素,能够影响犬尿酸的产生。 | |||
TMID-0021 |
Fruquintinib-d3
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Fruquintinib-d3 是 Fruquintinib 的氘代化合物。Fruquintinib 的 CAS 号为 1194506-26-7。Fruquintinib 是一种选择性的VEGFR 1/2/3抑制剂,它们的IC50值分别为33 nM、0.5 nM、35 nM。 | |||
T71055 |
Albendazole-d7
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Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben... | |||
TMIJ-0089 |
L-Valine-d8
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L-Valine-d8 是 L-Valine 的氘代化合物。L-Valine 的 CAS 号为 72-18-4。L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。 | |||
T77211 |
Sudan I-d5
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Sudan I-d5为Sudan I的一种氘代物。作为一种偶氮共轭红色染料(red dye),Sudan I常被作为油、溶剂或抛光剂的添加剂使用。此外,Sudan I能够抑制产气荚膜梭菌及鼠李糖菌的生长。 | |||
TMIJ-0476 |
Chlorotoluron-d6 (N,N-dimethyl-d6)
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Chlorotoluron-d6 (N,N-dimethyl-d6) 是 Chlorotoluron 的氘代化合物。Chlorotoluron 的 CAS 号为 15545-48-9。Chlorotoluron 是取代的苯基脲除草剂,普遍用于谷物作物的选择性杂草控制,是环境污染物。 | |||
TMID-0159 |
Indole-3-Acetic-d2 Acid
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Indole-3-Acetic-d2 Acid 是 Indole-3-Acetic Acid 的氘代化合物。Indole-3-Acetic Acid 的 CAS 号为 87-51-4。3-Indoleacetic acid 是常见的天然植物生长激素。它可以诱导植物细胞的伸长和分裂。 | |||
TMIJ-0265 |
Homovanillic Acid-13C-d3
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Homovanillic Acid-13C-d3 是 Homovanillic Acid 的 13C 和氘代化合物。Homovanillic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
TMID-0127 |
MINOXIDIL-d10
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MINOXIDIL-d10 是 MINOXIDIL 的氘代化合物。MINOXIDIL 的 CAS 号为 38304-91-5。Minoxidil 是一种是 ATP 敏感的钾通道 (KATP) 开放剂,可作为有效的口服降压药和外周血管舒张药,促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂,IC50为 20 μM。 | |||
TMIJ-0381 |
L-Valine-13C5-15N
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L-Valine-13C5-15N 是 L-Valine 的 13C 和 15 N 的标记化合物。L-Valine 的 CAS 号为 72-18-4。L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。 | |||
TMID-0284 |
Vancomycin-d12 TFA
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Vancomycin-d12 TFA 是 Vancomycin TFA 的氘代化合物。Vancomycin TFA 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素,用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。 | |||
TMID-0283 |
Vancomycin-13C-d3
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Vancomycin-13C-d3 是 Vancomycin 的 13C 和氘代化合物。Vancomycin 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素,用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。 | |||
T37250 |
Cefazolin-13C2,15N
Cefazolin-13C2,15N |
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Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50... | |||
T69758 |
Flutamide-d7
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Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo... | |||
TMID-0261 |
Indole-2,4,5,6,7-d5-3-acetic Acid
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Indole-2,4,5,6,7-d5-3-acetic Acid 是 Indole-3-acetic Acid 的氘代化合物。Indole-3-acetic Acid 的 CAS 号为 87-51-4。3-Indoleacetic acid 是常见的天然植物生长激素。它可以诱导植物细胞的伸长和分裂。 | |||
TMIH-0089 |
Androstenedione-d7
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Androstenedione-d7 是 Androstenedione 的氘代化合物。Androstenedione 的 CAS 号为 560-62-3。9-hydroxy-4-androstene-3,17-dione 是一种类固醇激素,具有抗肿瘤活性,可以抑制多种癌症细胞的生长,包括乳腺癌、前列腺癌和肺癌细胞。 | |||
TMID-0156 |
Indole-2,4,5,6,7-d5-3-acetic-2,2-d2 Acid
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Indole-2,4,5,6,7-d5-3-acetic-2,2-d2 Acid 是 Indole-3-acetic Acid 的氘代化合物。Indole-3-acetic Acid 的 CAS 号为 87-51-4。3-Indoleacetic acid 是常见的天然植物生长激素。它可以诱导植物细胞的伸长和分裂。 | |||
TMIH-0091 |
AOH-d3
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AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMIH-0025 |
13C-d3-AOH1996
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13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMID-0286 |
Rifaximin-d6
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Rifaximin-d6 是 Rifaximin 的氘代化合物。Rifaximin 的 CAS 号为 80621-81-4。Rifaximin是一种胃肠道选择性抗生素,与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合,抑制细菌 RNA 合成。与革兰氏阴性菌(MIC:8-50 毫克/毫升)相比,它对革兰氏阳性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。 | |||
TMID-0057 |
(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid
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(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid 是 (4-Hydroxy-3-methoxyphenyl)acetic Acid 的氘代化合物。(4-Hydroxy-3-methoxyphenyl)acetic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
TMIJ-0377 |
Thiamine Hydrochloride-13C4
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Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T38118 |
Zanamivir-13C,15N2
Zanamivir-13C,15N2 |
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Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intra... | |||
TMIJ-0157 |
Cefoperazone-d5
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Cefoperazone-d5 是 Cefoperazone 的氘代化合物。Cefoperazone 的 CAS 号为 62893-19-0。Cefoperazone是一种半合成的头孢菌素,有抗菌活性。 | |||
TMIJ-0417 |
2,4-D-d3
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2,4-D-d3 是 2,4-D 的氘代化合物。2,4-D 的 CAS 号为 94-75-7。2,4-Dichlorophenoxyacetic acid 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 | |||
T67921 |
Retinoic acid-d5
all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor | Metabolism |
Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂, 对 RARα/β/γ 的 IC50 为 14 nM,与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物,在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。 | |||
T71401 |
Oxaliplatin-d10
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Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.... | |||
T71293 |
Nifuroxazide-d4
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Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S... | |||
T69966 |
Roxadustat-d5
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Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ... | |||
TMIH-0065 |
Acalabrutinib-d4
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Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 | |||
TMIJ-0268 |
Relugolix-d6
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Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。 | |||
T35915 |
Erlotinib-13C6
Erlotinib-13C6 |
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Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]... |