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MS40, 作为一种WDR5 PROTAC,选择性降解WDR5及免疫调节化合物(IMiDs)的新底物:CRBN和Ikaros锌指(IKZF)转录因子IKZF1与IKZF3。MS40促使WDR5降解,导致MLL/KMT2A复合体从染色质上解离,从而降低H3K4me2的水平。在体外,MS40抑制了原发性白血病患者细胞的增长,在体内则抑制了患者源异种移植物的生长。
MS40, 作为一种WDR5 PROTAC,选择性降解WDR5及免疫调节化合物(IMiDs)的新底物:CRBN和Ikaros锌指(IKZF)转录因子IKZF1与IKZF3。MS40促使WDR5降解,导致MLL/KMT2A复合体从染色质上解离,从而降低H3K4me2的水平。在体外,MS40抑制了原发性白血病患者细胞的增长,在体内则抑制了患者源异种移植物的生长。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | MS40 is a WDR5 PROTAC that selectively degrades WDR5 and serves as a novel degrader for immune-modulating compounds (IMiDs), including the new substrates CRBN and Ikaros zinc finger (IKZF) transcription factors IKZF1 and IKZF3. MS40 facilitates the degradation of WDR5, resulting in the dissociation of the MLL/KMT2A complex from chromatin, thereby reducing H3K4me2 levels. In vitro, MS40 inhibits the growth of primary leukemia patient cells, and in vivo, it suppresses the expansion of patient-derived xenografts. |
别名 | MS-40, MS 40 |
分子量 | 995.1 |
分子式 | C52H61F3N10O7 |
CAS No. | 2407449-49-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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