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Cefoperazone (Medocef) 是一种半合成的头孢菌素,有抗菌活性。
Cefoperazone (Medocef) 是一种半合成的头孢菌素,有抗菌活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 198 | 现货 | |
1 g | ¥ 328 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 226 | 现货 |
产品描述 | Cefoperazone (Medocef) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217βG uptake (IC50: 199 μM). |
靶点活性 | [3H]-E217βG uptake (rMrp2-mediated):199 μM |
体内活性 | 经Cefoperazone (2 g, i.v.)处理后,根据给药时间不同,血清中的浓度范围为202μg/mL至375μg/mL。通过肌肉注射2 g Cefoperazone后,平均血清峰值浓度在1.5小时达到111μg/mL。在给药后12小时,平均血清水平仍为2至4μg/mL。Cefoperazone约90%与血清蛋白结合。 |
别名 | 头孢哌酮, Medocef, Cefob |
分子量 | 645.67 |
分子式 | C25H27N9O8S2 |
CAS No. | 62893-19-0 |
Smiles | C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](NC(=O)N3C(=O)C(=O)N(CC)CC3)C4=CC=C(O)C=C4)=O)C2=O)(SCC1CSC=5N(C)N=NN5)[H] |
密度 | 1.77 g/cm3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 91 mg/mL (140.9 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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