ER-076349 is a microtubule polymerization inhibitor that induces G2-M cell cycle arrest and disrupts mitotic spindles. This compound inhibits the growth of cancer cells and suppresses tumor growth in various human tumor xenograft mouse models. Additionally, ER-076349 is an analog of Halichondrin B.

ER-076349 在多种癌细胞中表现出抑制增殖的作用，具体表现在各种癌细胞线的IC 50 值上，分别为MDA-MB-435的0.59 nM, COLO 205的2.4 nM, DLD-1的7.3 nM, DU 145的3.6 nM, LNCaP的1.8 nM, LOX的3.2 nM, HL-60的2.6 nM, 以及U937的4.0 nM。