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Fusidic acid sodium salt

产品编号 T1289Cas号 751-94-0
别名 Sodium fusidate, 夫西地酸钠, Fusidate Sodium, Fucidin, SQ-16360

Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。

Fusidic acid sodium salt

Fusidic acid sodium salt

纯度: 99.17%
产品编号 T1289 别名 Sodium fusidate, 夫西地酸钠, Fusidate Sodium, Fucidin, SQ-16360Cas号 751-94-0

Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。

规格价格库存数量
100 mg¥ 282现货
200 mg¥ 397现货
500 mg¥ 638现货
1 mL x 10 mM (in DMSO)¥ 150现货
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纯度:99.17%
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产品介绍

生物活性
产品描述
Fusidic acid sodium salt (SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
体内活性
Fusidin(Fusidate Sodium)至少在一定程度上通过抑制TNF-α的分泌改善EAM[1]。Fusidin显著减轻了给予链脲佐菌素(SZ)的小鼠免疫炎症糖尿病的临床和组织学征象。该作用是剂量依赖性的,且在三个不同的小鼠品系中均有观察到。因此,Fusidin 可能具有抗糖尿病效应[2]。
激酶实验
Binding assays: Binding assays are performed as previously described (Allenby et al., 1993, 1994). Briefly, labeled and unlabeled retinoids are added to nucleosol or cytosolic fractions in ethanol so that the total amount of ethanol added is constant in all tubes and did not exceed 2% of the incubation volume. The receptor preparations are incubated with retinoids at 4°C for 4–6 hr. Sephadex PD-10 desalting columns are used to separate bound radioligand from free radioligand after equilib- rium is achieved. For competitive binding assays, varying concentrations of unlabeled competing ligand are incubated with the appropriate nucleosol or cytosol in the presence of a fixed concentration of [3H]tRA (sp. act. 49.3 Ci/mmol) or [3H]9-cis RA (sp. act. 24.0 Ci/mmol). Final concentrations of [3H] tRA and [3H]9-cis RA for nuclear receptor binding assays are 5 nM. Final concentrations of [3H] tRA for CRABP binding assays is 30 nM. The IC50s are calculated as described above (DeLean et al., 1978). For saturation kinetics, increasing concentrations of radiolabeled ligand ([3H]tRA sp. act. 49.3 Ci/mmol, [3H]TTNPB sp. act. 5.5 Ci/ mmol) are added to the nucleosol of the appropriate receptor subtype in the presence (nonspecific binding) or absence (total binding) of a 100-fold molar excess of the corresponding unlabeled retinoid. Specific binding is defined as the total binding minus nonspecific binding. Saturation kinetics are calculated as previously described (Scatchard, 1949; Grippo and Gudas, 1987; Levin et al., 1992).
别名Sodium fusidate, 夫西地酸钠, Fusidate Sodium, Fucidin, SQ-16360
化学信息
分子量538.69
分子式C31H47NaO6
CAS No.751-94-0
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
Ethanol: 93 mg/mL (172.6 mM)
H2O: 92 mg/mL (170.8 mM)
DMSO: 93 mg/mL (172.6 mM)
溶液配制表
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.8564 mL9.2818 mL18.5636 mL92.8178 mL
5 mM0.3713 mL1.8564 mL3.7127 mL18.5636 mL
10 mM0.1856 mL0.9282 mL1.8564 mL9.2818 mL
20 mM0.0928 mL0.4641 mL0.9282 mL4.6409 mL
50 mM0.0371 mL0.1856 mL0.3713 mL1.8564 mL
100 mM0.0186 mL0.0928 mL0.1856 mL0.9282 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
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2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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