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Candidalysin是一种最初从Candida albicans中分离出的细胞溶解性肽毒素,具有毒性和非毒性特性。它通过与宿主细胞的上皮生长因子受体 (EGFR) 相互作用,激活上皮细胞信号通路,激活基质金属蛋白酶 (MMP) 和钙离子内流,引发炎症反应和免疫细胞的募集。Candidalysin通过对宿主细胞膜的损伤表现出细胞毒性。
Candidalysin是一种最初从Candida albicans中分离出的细胞溶解性肽毒素,具有毒性和非毒性特性。它通过与宿主细胞的上皮生长因子受体 (EGFR) 相互作用,激活上皮细胞信号通路,激活基质金属蛋白酶 (MMP) 和钙离子内流,引发炎症反应和免疫细胞的募集。Candidalysin通过对宿主细胞膜的损伤表现出细胞毒性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Candidalysin is a cytolytic peptide toxin initially isolated from *Candida albicans*, exhibiting both toxic and non-toxic properties. It activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) on host cells, leading to the activation of matrix metalloproteinases (MMP) and calcium ion influx, which results in inflammatory responses and immune cell recruitment. Additionally, Candidalysin exhibits cytotoxicity by causing membrane damage to host cells. |
分子量 | 3310.11 |
分子式 | C153H266N38O38S2 |
CAS No. | 1906866-53-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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