Macrophage-activating lipopeptide-2 TFA is a lipopeptide agonist of Toll-like receptors TLR-2/TLR-6. This compound enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, improving vasodilation. Additionally, Macrophage-activating lipopeptide-2 increases leukocyte adhesion to endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).

Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) 通过促进主要内皮粘附分子和白细胞整合素受体的表达，增强白细胞在内皮的粘附能力。Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) 通过增加内皮 MyEnd 细胞中蛋白激酶 B 和 eNOS 的磷酸化，进而促进 NO 的释放。相关抗体包括 Macrophage-activating lipopeptide 2 TFA。

巨噬细胞活化脂肽2（1 µg 溶于 125 µL PBS中；每日一次；持续10天，静脉注射方式）对于经过实验性股动脉结扎（FAL）并且有高胆固醇血症的Apoe缺陷小鼠后肢灌注恢复及侧支生长有显著改善效果。