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Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 1,680 | 35日内发货 | |
50 mg | ¥ 6,890 | 35日内发货 |
产品描述 | Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women. |
体内活性 | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. |
别名 | 盐酸依氟乌氨酸, α-difluoromethylornithinehydrochloride, RMI71782hydrochloride, MDL71782hydrochloride, DFMO hydrochloride |
分子量 | 218.63 |
分子式 | C6H13ClF2N2O2 |
CAS No. | 68278-23-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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