BPI-9016M

Name: BPI-9016M
Brand: TargetMol
SKU: T10588
Rating: 4.5 (1 reviews)

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产品编号 T10588Cas号 1528546-94-2

BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma.

BPI-9016M

还可以

产品编号 T10588Cas号 1528546-94-2

BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma.

规格	价格	库存
2 mg	¥ 2,570	5日内发货
25 mg	¥ 12,800	8-10周
50 mg	¥ 16,800	8-10周
100 mg	¥ 21,500	8-10周

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产品描述	BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma.
体外活性	The IC50 of BPI-9016M in several lung adenocarcinoma cell lines ( A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM. BPI-9016M (3.1-50 μM) reduces the expression of c-Met, p-c-Met, p-AKT, and p-ERK in the H1299 and A549 cells in a dose-dependent manner. BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation. BPI-9016M (12.5-50 μM; 24 hours) induces the accumulation of more tumor cells in the G1 phase [2].
体内活性	In PDX xenografts in NOD/SCID mice, BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth [2].