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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 237 | 现货 | |
5 mg | ¥ 585 | 现货 | |
10 mg | ¥ 996 | 现货 | |
25 mg | ¥ 1,670 | 现货 | |
50 mg | ¥ 2,380 | 现货 | |
100 mg | ¥ 3,490 | 现货 | |
200 mg | ¥ 4,850 | 现货 |
产品描述 | Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1]. |
靶点活性 | EGFR:11.7 nM (DC50, HCC827(exon 19 del) cells), EGFR:22.3 nM (DC50, H3255 (L858R mutantion) cells) |
体外活性 | H3255细胞表达L858R EGFR,在Gefitinib-based PROTAC 3 (25 nM-10 μM; 24小时)处理下,以及HCC827细胞表达外显子19缺失EGFR,在Gefitinib-based PROTAC 3 (100 nM-10 μM; 24小时)处理下,可实现对包含L858R激活点突变的突变异构体以及外显子19缺失EGFR的降解,同时不影响WT EGFR[1]。 |
分子量 | 934.51 |
分子式 | C47H57ClFN7O8S |
CAS No. | 2230821-27-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 10 mM | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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