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Nanrilkefusp alfa (SO-C101; SOT101) 是一种选择性的强效融合蛋白,由IL-15和IL-15Rαsushi+结构域组成。该化合物通过增殖和激活记忆性 CD8+T 细胞、自然杀伤细胞、γ/δ T 细胞及自然杀伤 T 细胞,有效抑制肿瘤。在多种小鼠肿瘤模型中,Nanrilkefusp alfa 显著抑制肿瘤生长并防止黑色素瘤的远处转移。
Nanrilkefusp alfa (SO-C101; SOT101) 是一种选择性的强效融合蛋白,由IL-15和IL-15Rαsushi+结构域组成。该化合物通过增殖和激活记忆性 CD8+T 细胞、自然杀伤细胞、γ/δ T 细胞及自然杀伤 T 细胞,有效抑制肿瘤。在多种小鼠肿瘤模型中,Nanrilkefusp alfa 显著抑制肿瘤生长并防止黑色素瘤的远处转移。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 待询 | |
50 mg | 询价 | 待询 |
产品描述 | Nanrilkefusp alfa (SO-C101; SOT101), a fusion protein, serves as a powerful and selective agonist of the IL-15 and IL-15Rα sushi + domain. It promotes the proliferation and activation of memory CD8 + T cells, natural killer (NK) cells, γ/δ T cells, and NKT cells to inhibit tumor growth. Nanrilkefusp alfa demonstrates remarkable anti-metastatic effects in melanoma and effectively suppresses tumor progression in various mouse tumor models [1] [2]. |
体外活性 | Nanrilkefusp alfa, at concentrations ranging from 0.01 to 10 nM over 7 days, expands and activates NK cell subtypes from human PBMCs in vitro. At 1 nM for 20 hours, it induces cytotoxic and tumor cell-killing activity in human NK cell subtypes. Additionally, at 0.1, 1, and 10 nM for both 3-day and 7-day durations, it stimulates the expression of cytotoxic receptors NKp30, DNAM-1, and NKG2D on human NK cells [1]. |
体内活性 | Nanrilkefusp alfa administered subcutaneously at 2 mg/kg for 4 consecutive days over 2 weeks reduces tumor development and growth in the metastatic kidney cancer Renca mouse model, dependent on natural killer (NK) and CD8+ T cells. It also activates NK and CD8+ T cytotoxicity genes in the TC-1 tumor model. In the TRAMP-C2 tumor mouse model, intraperitoneal administration of Nanrilkefusp alfa at 1 mg/kg, with or without 12.5 mg/kg anti-PD-1, for 4 consecutive days over 2 weeks, reduces established tumor growth and expands CD8+ T cell and NK cell populations while sparing T regulatory cells (Tregs). The compound mediates inhibition of TRAMP-C2 tumor development, primarily relying on NK and CD8+ T cells. In both models, Nanrilkefusp alfa demonstrates effectiveness in activating immune cells and reducing tumor growth. |
别名 | SOT101, SO-C101 |
CAS No. | 1416390-27-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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