AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).

Ghrelin receptor (FLIPR assay):0.74 nM(EC50)

在大鼠中，AnaMorelin hydrochloride(ANAM) 显著并且依剂量增加食物摄取量(FI)和体重(BW)，与对照组相比，在所有剂量水平上都有所增加；在10或30 mg/kg的剂量下，显著增加生长激素(GH)水平。在猪中观察到，ANAM给药后GH和IGF-1水平增加[1]。

Fluorescent imaging plate reader and binding assays in HEK293 and baby hamster kidney cells determined the agonist and antagonist activity of ANAM, and its affinity for the ghrelin receptor. Rat pituitary cells were incubated with ANAM to evaluate its effect on growth hormone (GH) release. In vivo, rats were treated with ANAM 3, 10, or 30 mg/kg, or control orally, once daily for 6 days to evaluate the effect on food intake (FI) and body weight (BW), and once to assess GH response. In pigs, single (3.5 mg/kg) or continuous (1 mg/kg/day) ANAM doses were administered to assess GH and insulin-like growth factor (IGF-1) response[1].