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Anti-PDGFRB Monoclonal Antibody

产品编号 TMAZ-0120
别名 Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor beta, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor receptor

Anti-PDGFRB Monoclonal Antibody is a rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody can be used in ELISA, FACS.

Anti-PDGFRB Monoclonal Antibody

Anti-PDGFRB Monoclonal Antibody

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产品编号 TMAZ-0120 别名 Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor beta, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor receptor

Anti-PDGFRB Monoclonal Antibody is a rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 465.16¥ 8027日内发货
50 μg¥ 557.96¥ 9627日内发货
100 μg¥ 780.68¥ 1,3467日内发货
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产品介绍

生物活性
产品描述
Anti-PDGFRB Monoclonal Antibody is a rabbit antibody targeting PDGFRB. Anti-PDGFRB Monoclonal Antibody can be used in ELISA, FACS.
别名Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor beta, Platelet-derived growth factor receptor 1, Beta platelet-derived growth factor receptor
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of PDGFRB overexpressed 336F cells with TMAZ-0120, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PDGFRB protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin/APC/PE/AF488/AF555/AF647
可提供抗体种类
3
抗原信息
免疫原
PDGFRB
抗原种属
Human
基因ID
5159
Uniprot ID
研究领域
Cancer Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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