Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways.

Aurantiamide 在脂多糖（LPS）诱导的BV2微胶质细胞中通过抑制κB-α抑制子（IκB-α）的磷酸化，阻断了核因子-κB（NF-κB）的激活。此外，Aurantiamide 降低了c-Jun N端激酶（JNK）和p38丝裂原活化蛋白激酶（MAPKs）的磷酸化水平。据推测，Aurantiamide 通过抑制NF-κB、JNK和p38途径，对LPS刺激具有抗神经炎症作用[1]。Aurantiamide 通过抑制NF-κB途径，在IAV感染的细胞上展现了强大的抗病毒和抗炎作用。因此，Aurantiamide 可能是治疗流感的潜在疗法[2]。

The anti-viral activity of aurantiamide against Influenza A virus (IAV) was determined using the cytopathic effect (CPE) inhibition assay.?Viruses were titrated on Madin-Darby canine kidney (MDCK) cells by plaque assays.?Ribonucleoprotein (RNP) luciferase reporter assay was further conducted to investigate the effect of aurantiamide on the activity of the viral polymerase complex.?HEK293T cells with a stably transfected NF-κB luciferase reporter plasmid were employed to examine the activity of aurantiamide on NF-κB activation.?Activation of the host signaling pathway induced by IAV infection in the absence or presence of aurantiamide was assessed by western blotting.?The effect of aurantiamide on IAV-induced expression of pro-inflammatory cytokines was measured by real-time quantitative PCR and Luminex assays[2].