D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.

D,L-erythro-PDMP (0, 12, 25, 50 μM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts[1]. D,L-erythro PDMP (50 μM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology[1]. D,L-erythro-PDMP (40 μM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2]. D,L-erythro-PDMP (40 μM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide[2]. Cell Proliferation Assay[1]Cell Line: Rabbit skin fibroblast Concentration: 0, 12, 25, 50 μM Incubation Time: 0, 4, 7, 10 days Result: Showed an inhibitory effect on cell growth. Cell Cytotoxicity Assay[1]Cell Line: Rabbit skin fibroblast Concentration: 50 μM Incubation Time: 3 days Result: Had cytotoxic on cell morphology.