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BQU57

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产品编号 T2267Cas号 1637739-82-2

BQU57 能够选择性抑制 Ral,且对 Ral 的选择性高于 Ras、Rho,能够作用于 H2122(IC50:2.0 μM)和 H358(IC50:1.3 μM)。

BQU57
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BQU57

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纯度: 98.72%
产品编号 T2267Cas号 1637739-82-2

BQU57 能够选择性抑制 Ral,且对 Ral 的选择性高于 Ras、Rho,能够作用于 H2122(IC50:2.0 μM)和 H358(IC50:1.3 μM)。

规格价格库存数量
1 mg¥ 145现货
2 mg¥ 197现货
5 mg¥ 325现货
10 mg¥ 559现货
25 mg¥ 858现货
50 mg¥ 1,190现货
100 mg¥ 2,230现货
200 mg¥ 3,180现货
1 mL x 10 mM (in DMSO)¥ 359现货
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TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性
产品描述
BQU57 selectively inhibits Ral over Ras or Rho and suppresses xenograft tumor growth.
体外活性
50 mg/kg,i.p. BQU57在负荷人肺H2122肿瘤的小鼠体内,明显抑制RalA和RalB的活化,并且剂量依赖性抑制肿瘤生长.
体内活性
BQU57抑制H2122和H358细胞系中RalA与RalB活化,从而引起细胞生长抑制。
激酶实验
HDAC Enzyme Assay: The commercially availablae human recombinant enzyme and fluorogenic HDAC assay kits have used to measure percent inhibition and IC50 values of three HDAC isozymes (HDAC2, HDAC4, HDAC6). Briefly, the inhibitor is added sequentially to a black, flat-bottom 96-well microtiter plate, and the reaction mixture is incubated for 30 min at 37°C. The potent HDAC inhibitor trichostatin A (included in the assay kit) is added to the bifunctional HDAC assay developer at a final reaction concentration of 1 μM to stop deacetylation and initiate the release of the fluorophore. The reaction mixture is further incubated at room temperature for 15 min. Fluorescence is measured on a Spectra Max Gemini XPS using an excitation wavelength of 360 nm and a detection wavelength of 460 nm.
细胞实验
Growth inhibition on human lung cancer cells by the compounds are measured under anchorage-independent conditions in soft agar. Cells are seeded into 6-well plates (coated with a base layer made of 2.0 mL of 1% low-melting-point agarose) at 15,000 cells per well in 3.0 mL of 0.4% low-melting-point agarose containing various concentration of drug. Two to four weeks (depending on cell line) after incubation, cells are stained with 1.0 mg/mL Nitro Blue Tetrazolium and colonies are counted under a microscope. The IC50 values are defined as the concentration of drug that resulted in 50% reduction in colony number compared to DMSO treated control. After 48 hr, cells are subjected to the soft agar colony formation assay. (Only for Reference)
化学信息
分子量334.3
分子式C16H13F3N4O
CAS No.1637739-82-2
SmilesCc1nn(C)c2OC(N)=C(C#N)C(c12)c1ccc(cc1)C(F)(F)F
密度1.43 g/cm3 (Predicted)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
Ethanol: 16 mg/mL (47.9 mM)
DMSO: 40 mg/mL (119.65 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9913 mL14.9566 mL29.9133 mL149.5663 mL
5 mM0.5983 mL2.9913 mL5.9827 mL29.9133 mL
10 mM0.2991 mL1.4957 mL2.9913 mL14.9566 mL
20 mM0.1496 mL0.7478 mL1.4957 mL7.4783 mL
DMSO
1mg5mg10mg50mg
50 mM0.0598 mL0.2991 mL0.5983 mL2.9913 mL
100 mM0.0299 mL0.1496 mL0.2991 mL1.4957 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

对于不同动物的给药剂量换算,您也可以参考 更多

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