Name: Imgatuzumab
Brand: TargetMol
SKU: T76811
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 2,490

2-4周

5 mg

¥ 7,470

2-4周

10 mg

¥ 12,000

2-4周

生物活性

产品描述	Imgatuzumab (RG 7160; GA201) is a humanized, glycoengineered IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). This product inhibits EGFR-mediated signaling (such as MAPK and PI3K pathways) by blocking EGF binding and inducing receptor internalization. As a glycoengineered antibody, Imgatuzumab features enhanced affinity for Fc gamma RIIIa, resulting in potent antibody-dependent cellular cytotoxicity (ADCC). It is used to research EGFR-overexpressing solid tumors and demonstrates synergistic effects when combined with chemotherapeutic agents.
体外活性	Imgatuzumab 特异性结合 EGFR，并在 A549 和 HCT116 细胞中表现出强效 ADCC 活性。实验显示，与吉西他滨、顺铂、紫杉醇联用或地塞米松预处理均不削弱其介导的 ADCC 作用，且联合治疗可增强整体抗肿瘤效力 [1]。
体内活性	Imgatuzumab 显著抑制肺癌和结直肠癌异种移植模型小鼠的肿瘤生长。与吉西他滨或紫杉醇联用可显著促进肿瘤消退并延长生存期，展现出比单药治疗更强的抗肿瘤效力 [1]。
别名	伊马曲单抗, RO 5083945, RG 7160, Anti-EGFR Recombinant Antibody
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P00533
靶点	EGFR

化学信息

分子量	145.0 kDa
CAS No.	959963-46-3

储存&溶解度

存储

Imgatuzumab