Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.

Apoptosis inducer 30 对多种肿瘤细胞系展示了显著的抑制作用，其IC 50 值针对 A549、HepG2、MCF-7、HeLa 和 MCF-10A 细胞系分别为 1.01、0.91、0.32、0.95、8.09 μM。此外，在 MCF-7 细胞中, Apoptosis inducer 30 (100-500 nM, 48 小时) 能够显著增加 Cyt-C 水平，并触发 caspase-9 和 caspase-7 激活。