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GTI-2040 是一种硫代寡核苷酸,靶向人 ribonucleotide reductase R2 mRNA。在体外通过下调 ribonucleotide reductase R2 表达抑制癌细胞增殖,并在小鼠人类癌症异种移植模型中显著抑制肿瘤生长。
GTI-2040 是一种硫代寡核苷酸,靶向人 ribonucleotide reductase R2 mRNA。在体外通过下调 ribonucleotide reductase R2 表达抑制癌细胞增殖,并在小鼠人类癌症异种移植模型中显著抑制肿瘤生长。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 待询 | |
50 mg | 询价 | 待询 |
产品描述 | GTI-2040, a 20-mer phosphorothioate oligonucleotide, targets the mRNA sequence of human ribonucleotide reductase R2 for hybridization. This compound inhibits cancer cell proliferation by reducing R2 expression in vitro and markedly suppresses tumor growth in xenograft models of human cancer in mice. |
CAS No. | 236391-66-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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