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Targets Recommended: Hedgehog/Smoothened

1914

抑制剂 & 化合物

755

天然产物

8

化合物库

409

重组蛋白

60

同位素标记化合物

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Cat. No.	Product Name
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；
L4900	心血管毒性化合物库		131 compounds
	131 种心血管毒性化合物的独特集合，可用于毒理学研究；
L8110	细胞重编程化合物库		1813 compounds
	1813 种重编程信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选
L4010	已知活性化合物库		22555 compounds
	22555 个已知活性化合物的集合，可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认；
L9700	内质网应激化合物库		193 compounds
	193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；
L8700	铁死亡化合物库		779 compounds
	779 种与铁死亡通路相关的化合物，可用于高通量和高内涵筛选；
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L6720	抗COVID-19中药单体库		1147 compounds
	根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂，收集了1147 种相关中药来源的单体化合物，可用于高通量和高内涵筛选，是抗新冠病毒药物研发的良好工具；

化合物库

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

心血管毒性化合物库

Cat.No: L4900

Compounds: 131

细胞重编程化合物库

Cat.No: L8110

Compounds: 1813

已知活性化合物库

Cat.No: L4010

Compounds: 22555

内质网应激化合物库

Cat.No: L9700

Compounds: 193

铁死亡化合物库

Cat.No: L8700

Compounds: 779

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

抗COVID-19中药单体库

Cat.No: L6720

Compounds: 1147

Cat. No.	Product Name	Target	Signaling Pathways
T23027	MRT-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂，通过多种 Hedgehog (Hh) 测定，其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。
T9266	Fatostatin	Lipid; Fatty Acid Synthase	Metabolism
	Fatostatin A 是一种SREBP 活化的特异性抑制剂，能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性，能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。
T5491	GSK3179106	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂，对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应，对肠易激综合征具有潜在的应用价值。
T9614	MERS-CoV-IN-1	SARS-CoV	Microbiology/Virology
	MERS-CoV-IN-1 对冠状病毒的活性具有优异的抑制作用，可用作预防冠状病毒引起疾病的药物组合物。
T23312	SB 204741	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 204741 是一种选择性的5-HT2B 拮抗剂，具有高亲和性，pKi 值为7.1。
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
TQ0105	CAY10650	Phospholipase	Metabolism
	CAY10650 是高效的胞浆磷脂酶A2α抑制剂，IC50=12 nM，能够抑制脂滴形成和 PGE2 分泌。
T7954	YM976	PDE	Metabolism
	YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。
T1997	JNJ-31020028 JNJ 31020028	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂，对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22，其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。
T8235	L-732138	Neurokinin receptor	GPCR/G Protein; Neuroscience
	L-732138 是选择性有效和竞争性神经激肽-1受体拮抗剂，IC50为 2.3 nM，可减轻痛觉过敏并具有抗肿瘤作用。它在克隆的人 NK-1受体中的效力比在克隆大鼠 NK-1受体中高 200 倍，比人类 NK-2 和 NK-3 受体高 1000 倍以上。
T16481	PF-04995274	5-HT Receptor	GPCR/G Protein; Neuroscience
	PF-04995274 是强效，高亲和力，口服活性血清素 4 受体的部分激动剂。它是可脑渗透的，可用于与阿尔茨海默症相关的认知障碍的研究。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T8496	MAZ51	Apoptosis; VEGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活，而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡，具有抗肿瘤活性。
T1893	Parmodulin 2 ML 161	Protease-activated Receptor	GPCR/G Protein
	Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂，IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂，可以抑制体外血小板聚集和体内血小板血栓形成。
T2040	OAC1 BAS 00287861	OCT	Membrane transporter/Ion channel
	OAC1 (BAS 00287861) 是一种能够激活 Octamer 结合转录因子 4 的化合物。它提高了 iPSC 重编程效率并加速重编程过程。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T20759	XRP44X XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras	GPCR/G Protein; MAPK
	XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T9138	Indirubin-3′-oxime Indirubin-3'-monoxime	GSK-3; CDK; JNK	Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。
T39308	Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂，可抑制 Fas 介导的吞噬作用和氧化破裂抑制，但对 IL-8 的趋化活性无影响。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T0947	Dexamethasone acetate Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体，有抗炎和免疫抑制活性。它可研究眼部感染。
T1790	Fosaprepitant dimeglumine 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
T5857	Trametinib (DMSO solvate) Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis; MEK	Apoptosis; MAPK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂，抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬，诱导凋亡。
T10239	Acolbifene 阿考比芬,EM-652,SCH 57068	Estrogen Receptor/ERR	Endocrinology/Hormones
	Acolbifene (SCH 57068) 是一种选择性雌激素受体拮抗剂，对雌二醇诱导的 ERα 和 ERβ 转录活性的 IC50 分别为 2 nM 和 0.4 nM。 Acolbifene 显示出抗癌特性。
T21584	CP 465022	iGluR	Membrane transporter/Ion channel; Neuroscience
	CP 465022 hydrochloride 是强效的、选择性的AMPA 受体非竞争性拮抗剂，具有抗惊厥活性。CP 465022 hydrochloride 在大鼠皮层神经元中抑制Kainate 诱导的反应 (IC50= 25 nM)。
T14848	C 87	Others; TNF	Apoptosis; Others
	C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合，有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM)，并有效阻断 TNF-α 触发的信号传导活动。
T16850	SB-265610 GSK-CXCR2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂，可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 和 70 nM。
T7604	Valrubicin Valstar,AD-32,戊柔比星	Antibiotic; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Valrubicin (AD-32) 是一种具有抗炎和抗肿瘤作用的化疗剂，能够抑制 TPA 和 PDBu 诱导的 PKC 活化，IC50值分别为 0.85 和 1.25 μM。
T5133	Dabigatran Etexilate Mesylate 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate	Thrombin	Proteases/Proteasome
	Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药，具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T33647L	Nesosteine Lithium Nesosteine Lithium(84233-61-4 Free baes)	Others	Others
	Nesosteine Lithium 是一种新型的粘液调节剂，对豚鼠 Herxheimer 微休克具有抑制作用且抑制卵清蛋白诱导的组胺在致敏动物气管中的释放。Nesosteine Lithium 能够保护致敏动物免受卵清蛋白诱导的支气管痉挛但对组胺和乙酰胆碱诱导的支气管痉挛无效。
T79600	Zharp2-1	RIP kinase	Apoptosis; NF-κB
	Zharp2-1是一种 RIPK2 抑制剂，抑制了 MDP 诱导或单核细胞增生李斯特菌感染诱导的炎症细胞因子的转录，缓解MDP诱导的小鼠腹膜炎症状，可用于研究炎症性肠病 (IBD)。
T28655	Sabeluzole R 58735,R58735,R-58735	Microtubule Associated	Cytoskeletal Signaling
	Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用，抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用，可用于研究阿尔茨海默症。
T26091	Riparin III Riparin	Antioxidant; Calcium Channel	Membrane transporter/Ion channel; Metabolism; oxidation-reduction
	Riparin III (Riparin) 是一种平滑肌松弛剂，抑制 CaCl2 诱导的收缩。Riparin III 具有潜在的抗氧化、抗炎和抗抑郁，可逆转皮质酮诱导的异常行为和神经化学改变。
T27102	CV-6209 CV6209,CV 6209	PAFR; AChE	GPCR/G Protein; Neuroscience
	CV-6209 是一种具有选择性和高效性的血小板活化因子 (PAF) 拮抗剂，具有抗增殖作用，部分抑制乙酰胆碱诱导的低血压，抑制 Paf 诱导的 PMN 或血小板聚集。CV-6209 具有抗幽门螺杆菌作用，可以抑制 PAF 引起的大鼠低血压。
T7102	BCTC N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺	TRP/TRPV Channel	Membrane transporter/Ion channel
	BCTC 是有效的、特异性的瞬时受体阳离子通道M8(TRPM8)抑制剂。
T0235	Modaline sulfate	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Modaline sulfate 是一种 MAO 抑制剂，用于研究抑郁症。
T37292	M62812	TLR	Immunology/Inflammation
	M62812是一种 TLR4抑制剂，可在 HEK239细胞中抑制 LPS 诱导的NF-κB 活化。
T14551	Bevenopran CB-5945,ADL-5945	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.
T15681	L-161982	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-161982 是选择性的 EP4 受体拮抗剂。L-161982 可以抑制 PGE2 诱导的 HCA-7 细胞 ERK 磷酸化和细胞增殖。L-161982 可以缓解胶原诱导的小鼠关节炎。
T34435	RU 47213 RU-47213,Itameline,RU47213	Others	Others
	RU 47213 可用于抑制东莨菪碱诱导的大鼠工作记忆障碍。
T3106	C-DIM12	Apoptosis; Others	Apoptosis; Others
	C-DIM12是一种人工合成的Nurr1激活剂，可诱导Nurr1和DA 基因表达。
T74186	PROTAC-O4I2	Apoptosis; PROTACs	Apoptosis; PROTAC
	PROTAC-O4I2 是一种靶向剪接因子 3B1 (SF3B1) 的 PROTAC连接体，在 K562 细胞中促使 FLAG-SF3B1 降解，IC50 值为 0.244 μM。PROTAC-O4I2 促使 K562 WT 细胞凋亡 (apoptosis)。
T10413	Autogramin-1	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Autogramin-1可以有效抑制由饥饿诱导和 Rapamycin (通过抑制 mTORC1) 诱导的自噬，IC50分别为 0.17 μM 和 0.44 μM。
T25450	GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB; Rho	Cell Cycle/Checkpoint; NF-κB
	GGTI 2147 降低 Rac1 活性，下调 p65 的表达，改善 OGD/R 诱导的神经元凋亡。
T68025	Zoliprofen	Others	Others
	Zoliprofen 是一种一种高效的且可口服的非甾体抗炎剂，具有抗炎、解热和镇痛活性，对角叉菜素、制霉菌素、刀豆球蛋白A 诱导的大鼠爪水肿，以及抗大鼠兔血清诱导的骨折或背皮水肿具有抑制作用。Zoliprofen 在大鼠和兔子中对胶原蛋白或花生四烯酸引起的血小板聚集方面比布洛芬和非诺洛芬有效20倍。Zoliprofen 对小鼠内毒素诱导的腹泻和花生四烯酸诱导的兔急性死亡抑制作用显著。
T36619	Aligeron	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aligeron 是一种非选择性的prostaglandin (PG)拮抗剂，对PGF2α和PGE2诱导的猫血压下降有抑制作用，可用于抑制PGF2α诱导的小鼠腹泻和PGE2诱导的大鼠爪水肿。Aligeron 对血管并发症具有抗氧化保护作用。
T64394	GW 833972A	Cannabinoid Receptor	GPCR/G Protein
	GW 833972A 是一种选择性的 CB2 受体激动剂。GW 833972A 对诱导神经去极化具有抑制作用，且在动物模型中对柠檬酸引起的咳嗽具有抑制作用。
T12108	MRS1845	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	MRS1845 是一种 ORAI1 抑制剂和钙进入（SOCE）阻滞剂，可阻断VP 诱导的 SOCE、OS 和 Ca（2+）沉积。
T72662	NMDAR/TRPM4-IN-2	ERK; TRP/TRPV Channel; NMDAR; iGluR	MAPK; Membrane transporter/Ion channel; Neuroscience
	NMDAR/TRPM4-IN-2 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。NMDAR/TRPM4-IN-2 具有神经保护活性，可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍，其 IC50 值为 2.1 μM。

化合物

Cat.No: T23027

Target: Hedgehog/Smoothened

Cat.No: T9266

Target: Lipid, Fatty Acid Synthase

Cat.No: T5491

Target: c-RET

Cat.No: T9614

Target: SARS-CoV

Cat.No: T23312

Target: 5-HT Receptor

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: TQ0105

Target: Phospholipase

Cat.No: T7954

Target: PDE

Cat.No: T1997

Synonym: JNJ 31020028

Target: Neuropeptide Y Receptor

Cat.No: T8235

Target: Neurokinin receptor

Cat.No: T16481

Target: 5-HT Receptor

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

Cat.No: T8496

Target: Apoptosis, VEGFR

Cat.No: T1893

Synonym: ML 161

Target: Protease-activated Receptor

Cat.No: T2040

Synonym: BAS 00287861

Target: OCT

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

Cat.No: T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Target: Ras

Indirubin-3′-oxime

Cat.No: T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

Boc-Asp(OMe)-fluoromethyl ketone

Cat.No: T39308

Synonym: Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK

Target: Caspase

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Dexamethasone acetate

Cat.No: T0947

Synonym: Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy, ADC Cytotoxin

Fosaprepitant dimeglumine

Cat.No: T1790

Synonym: 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt

Target: Neurokinin receptor

Trametinib (DMSO solvate)

Cat.No: T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

Cat.No: T10239

Synonym: 阿考比芬,EM-652,SCH 57068

Target: Estrogen Receptor/ERR

Cat.No: T21584

Target: iGluR

Cat.No: T14848

Target: Others, TNF

Cat.No: T16850

Synonym: GSK-CXCR2

Target: CXCR

Cat.No: T7604

Synonym: Valstar,AD-32,戊柔比星

Target: Antibiotic, PKC

Dabigatran Etexilate Mesylate

Cat.No: T5133

Synonym: 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate

Target: Thrombin

Nesosteine Lithium

Cat.No: T33647L

Synonym: Nesosteine Lithium(84233-61-4 Free baes)

Target: Others

Cat.No: T79600

Target: RIP kinase

Cat.No: T28655

Synonym: R 58735,R58735,R-58735

Target: Microtubule Associated

Cat.No: T26091

Synonym: Riparin

Target: Antioxidant, Calcium Channel

Cat.No: T27102

Synonym: CV6209,CV 6209

Target: PAFR, AChE

Cat.No: T7102

Synonym: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

Target: TRP/TRPV Channel

Modaline sulfate

Cat.No: T0235

Target: MAO, Monoamine Oxidase

Cat.No: T37292

Target: TLR

Cat.No: T14551

Synonym: CB-5945,ADL-5945

Target: Opioid Receptor

Cat.No: T15681

Target: Prostaglandin Receptor

Cat.No: T34435

Synonym: RU-47213,Itameline,RU47213

Target: Others

Cat.No: T3106

Target: Apoptosis, Others

Cat.No: T74186

Target: Apoptosis, PROTACs

Cat.No: T10413

Target: mTOR, Autophagy

Cat.No: T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Cat.No: T68025

Target: Others

Cat.No: T36619

Target: Prostaglandin Receptor

Cat.No: T64394

Target: Cannabinoid Receptor

Cat.No: T12108

Target: Calcium Channel

NMDAR/TRPM4-IN-2

Cat.No: T72662

Target: ERK, TRP/TRPV Channel, NMDAR, iGluR

Cat. No.	Product Name	Target	Signaling Pathways
T6S1027	Tussilagone	Others	Others
	Tussilagone 是Tussilago farfara 的主要活性成分，具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应，提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T4S0537	Neoline Bullatine B,雪上一枝蒿乙素	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Neoline 是一种乌头根 (PA) 的活性成分，可改善奥沙利铂引起的小鼠周围神经病变。Neoline 通对Nav1.7 电压门控钠通道电流 (VGSC)有抑制作用。它可用作标记化合物，从而测定用于研究神经性疼痛的 PA 产品的质量。
T2988	(-)-Epigallocatechin Gallate Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG	Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	(-)-Epigallocatechin Gallate (EGCG) 属于茶类黄酮天然产物，可抑制 EGFR 信号传导，抑制 GLUD 1/2。(-)-Epigallocatechin Gallate 具有抗氧化、抗炎和抗肿瘤活性。(-)-Epigallocatechin Gallate 可以通过激活细胞色素 c 氧化酶来诱导氧化磷酸化。
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
TN1624	Ethyl cinnamate	Calcium Channel; ROS; NO Synthase	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ethyl cinnamate 是食品香料和化妆品添加剂，也是哺乳动物组织的优良清除剂。
T30451	Biliatresone	Others	Others
	Biliatresone 是一种从球藻 Dysphania glomulifera 和 D. littoralis 中分离出来的环境毒素，诱导 C57BL/6J 新生儿胆管病，诱导谷胱甘肽（GSH）水平降低，诱导 SOX17 胆管细胞水平显着降低，诱导小鼠肝外胆管细胞损伤和纤维化。
T3S0488	Syringaresinol diglucoside Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷	Others	Others
	Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。
TN2315	Xanthopurpurin 茜草红素,1,3-二羥蒽醌,异茜草素	Platelet aggregation; Antifection	Microbiology/Virology; Others
	Xanthopurpurin 是分离自Rubia akane 根茎的蒽醌苷。Xanthopurpurin 主要对胶原诱导的血小板聚集有较强的抑制作用。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
T3860	Isoliquiritin apioside	MMP; p38 MAPK; NF-κB	MAPK; NF-κB; Proteases/Proteasome
	Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成，显著降低 PMA 诱导的MMP9活性增加，并抑制 PMA 诱导的MAPK 和NF-κB 活化。
TN1256	3-O-Acetyl-16α-hydroxytrametenolic acid 3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid	Immunology/Inflammation related	Immunology/Inflammation
	3-O-Acetyl-16α-hydroxytrametenolic acid 是茯苓中的一种萜类物质，具有抗氧化、抗癌作用。
TN1031	Poricoic acid B 茯苓酸B,茯苓新酸 B	Others	Others
	Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。
TN3460	Asebogenin	Antifungal	Microbiology/Virology
	Asebogenin 是从丹参中分离出来的化合物，具有抗真菌活性，对GPVI 诱导的血小板反应有抑制作用，抑制促炎刺激诱导的 NET 形成。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
TN2540	1-Hydroxybaccatin I	Others	Others
	1-Hydroxybaccatin I 对对苯醌诱导的腹部收缩具有显着的镇痛活性。
T6S1423	Praeruptorin B	Others	Others
	Praeruptorin B 在体外能抑制促癌因子诱导的现象。
T0632	3,4,5-Trimethoxybenzoic acid Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚	Antioxidant	oxidation-reduction
	3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) 是一种苯甲酸衍生物，可用作医药和有机合成中的砌块。
TN1038	Galgravin	Apoptosis	Apoptosis
	Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。
T4S1725	Galanthamine Galantamine,加兰他敏	Apoptosis; AChE	Apoptosis; Neuroscience
	Galanthamine (Galantamine) 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。
T2804	Panaxatriol 人参三醇,Panaxtriol	Others	Others
	Panaxatriol (Panaxtriol) 是一种能够减轻由于辐射损伤造成的骨髓抑制的天然产物。
T8024	3-Indoleacetonitrile	Others; Endogenous Metabolite	Metabolism; Others
	3-Indoleacetonitrile 是内源性代谢产物的一种。
T5760	(-)-Salutaridine 清风藤碱,SINOACUTINE	Others	Others
	(-)-Salutaridine 是一种生物碱。
T2916	Patchouli alcohol 百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇	Antibacterial; Antifungal	Microbiology/Virology
	Patchouli alcohol (Patchoulol) 是一种从广藿香中提取的天然三环倍半萜，有抗幽门螺杆菌和抗炎活性。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T8704	4-hydroxyphenyl acetate	Nrf2	Immunology/Inflammation
	4-hydroxyphenyl acetate 通过作为 NRF2 稳定剂防止 RPE 氧化应激诱导的坏死。
T4035	Khasianine	Others	Others
	Khasianine 是一种从茄属植物Solanum Nigrum L 中提取的甾体糖生物碱，具有抗肿瘤作用。
T5764	Alliin 蒜氨酸,(S)-3-(Allylsulphinyl)-L-alanine	NF-κB; PPAR	DNA Damage/DNA Repair; Metabolism; NF-κB
	Alliin ((S)-3-(Allylsulphinyl)-L-alanine) 是一种从大蒜中提取的亚砜化合物，具有口服活性，表现出降血糖、抗氧化和抗炎特性。
T5S1097	Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱	Apoptosis; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱，可强效抑制NF-κB 激活，具有抗肿瘤活性。
T5702	Tenuifoliside B	Dehydrogenase	Metabolism
	Tenuifoliside B 是一种分离自Polygalae Radix 中的成分，能够抑制氰化钾引起的缺氧和东莨菪碱引起的记忆障碍。它有成为 AD 先导化合物的潜力。它具有潜在的认知改善和脑保护作用。
T24711	Ricinine 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,蓖麻碱,Ricinin,Ritsinin	Others	Others
	Ricinine (1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile) 是蓖麻植物中的一种主要生物碱，在 CCl4 诱导的肝损伤中具有保肝作用。
TN2436	4-methyl-6-phenyl-2H-pyranone 4-methyl-6-phenyl-2H-pyranone	Mitochondrial Metabolism	Metabolism
	4-methyl-6-phenyl-2H-pyranone 源自黄芩黄芩，可改善线粒体功能以保护星形胶质细胞免受过氧化氢诱导的毒性。
T1156	Palonosetron hydrochloride 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259	5-HT Receptor	GPCR/G Protein; Neuroscience
	Palonosetron hydrochloride (RS 25259) 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。
TN4956	Scandoside	NF-κB; MAPK	MAPK; NF-κB
	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation.
TN1441	Beta-Tocopherol β-生育酚,BETA-生育酚	ERK; MAPK	MAPK
	Beta-Tocopherol 对由 phorbol 12-myristate 13-acetate (PMA) 诱导的人红白血病细胞 (HEL) 粘附有影响。
TN1599	Eburicoic acid Eburicoicacid,MFCD00238594,ZINC4655149,齿孔菌酸	Antioxidant; TNF; NOS; NO Synthase; CCR; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Microbiology/Virology; oxidation-reduction
	Eburicoic acid (ZINC4655149) 具有抗炎和抗氧化活性，从而保护肝脏免受 CCl4 引起的肝损伤，可用于抗肝癌研究。
TN6975	Cirsiumaldehyde 5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation	Others
	Cirsiumaldehyde 是一种从Lobelia chinensis、Cornus officinalis 成熟果实和 Hippophae rhamnoides 果实中分分离出的化合物。Cirsiumaldehyde 在胶原蛋白存在下对 U46619 诱导（1~5 uM）的大鼠血小板聚集的抑制浓度为 0.8~1.0 ug/mL。
T3717	Hinokitiol 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇	DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2	Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分，可抑制紫外线 B 诱导的角质形成细胞凋亡，可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。
TN2354	Methylnissolin 3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷	ERK; PDGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	Methylnissolin 是从黄芪中分离的一种天然产物，可抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖，IC50为 10 μM。。它通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化，具有抗菌和抗癌作用。
TN1984	Neoisoliquiritin	Others	Others
	Neoisoliquiritin 是一种提取自甘草中的活性物质。
TWS0704	N-Methylnuciferine	Others	Others
	N-Methylnuciferine 是一种从Lotus Plumule提取的生物碱，可改善脂多糖诱导的抑郁样行为。
TN1353	N-Benzyllinoleamide (9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺	Others	Others
	N-Benzyllinoleamide ((9Z,12Z)-N-Benzyloctadeca-9,12-dienamide) 是一种分离自 Lepidium meyeniiWalp，能够抗运动性疲劳的药物。
TN2330	Phenethyl ferulate Caffeic Acid 3-Methyl Phenethyl Ester,阿魏酸苯乙酯,阿魏酸苯乙醇酯	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) 对化学诱导的结肠癌具有化学预防特性，可增强偶氮甲烷诱导的结肠肿瘤的细胞凋亡。它抑制环氧合酶(COX) 和 5-脂氧合酶 (5-LOX) ，IC50 值分别为 4.35 和 5.75 μM。
TMA1570	Sappanone A	NF-κB; Nrf2	Immunology/Inflammation; NF-κB
	Sappanone A 是一种高异黄烷酮，通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。
TN1983	Neoisoastilbin	IL Receptor; TNF; NO Synthase	Apoptosis; Immunology/Inflammation
	Neoisoastilbin 具有抗炎、抗氧化、抗尿酸过多等生物特性。
TN1643	Ferulamide 4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺	PAFR; AChR	GPCR/G Protein; Neuroscience
	Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物，具有抗胆碱酯酶活性。
T3793	(20R)-Ginsenoside Rh1 20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1	Others	Others
	(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) 是 Ginsenoside Rh1 的 R 型异构体，分离自 Panax Ginseng 中，能够阻碍凝血酶诱导的纤维蛋白原向纤维蛋白的转化。
TQ0218	Deoxyandrographolide 去氧穿心莲内酯,14-deoxyandrographolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。
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天然产物

Cat.No: T6S1027

Target: Others

Cat.No: T5826

Target: HSP

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

Cat.No: T4S0537

Synonym: Bullatine B,雪上一枝蒿乙素

Target: Others, Sodium Channel

(-)-Epigallocatechin Gallate

Cat.No: T2988

Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

Ethyl cinnamate

Cat.No: TN1624

Target: Calcium Channel, ROS, NO Synthase

Cat.No: T30451

Target: Others

Syringaresinol diglucoside

Cat.No: T3S0488

Synonym: Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷

Target: Others

Cat.No: TN2315

Synonym: 茜草红素,1,3-二羥蒽醌,异茜草素

Target: Platelet aggregation, Antifection

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Isoliquiritin apioside

Cat.No: T3860

Target: MMP, p38 MAPK, NF-κB

3-O-Acetyl-16α-hydroxytrametenolic acid

Cat.No: TN1256

Synonym: 3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid

Target: Immunology/Inflammation related

Poricoic acid B

Cat.No: TN1031

Synonym: 茯苓酸B,茯苓新酸 B

Target: Others

Cat.No: TN3460

Target: Antifungal

Cat.No: T6S2099

Target: Antioxidant, TNF

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

1-Hydroxybaccatin I

Cat.No: TN2540

Target: Others

Cat.No: T6S1423

Target: Others

3,4,5-Trimethoxybenzoic acid

Cat.No: T0632

Synonym: Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚

Target: Antioxidant

Cat.No: TN1038

Target: Apoptosis

Cat.No: T4S1725

Synonym: Galantamine,加兰他敏

Target: Apoptosis, AChE

Cat.No: T2804

Synonym: 人参三醇,Panaxtriol

Target: Others

3-Indoleacetonitrile

Cat.No: T8024

Target: Others, Endogenous Metabolite

(-)-Salutaridine

Cat.No: T5760

Synonym: 清风藤碱,SINOACUTINE

Target: Others

Patchouli alcohol

Cat.No: T2916

Synonym: 百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇

Target: Antibacterial, Antifungal

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

4-hydroxyphenyl acetate

Cat.No: T8704

Target: Nrf2

Cat.No: T4035

Target: Others

Cat.No: T5764

Synonym: 蒜氨酸,(S)-3-(Allylsulphinyl)-L-alanine

Target: NF-κB, PPAR

Cat.No: T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Target: Apoptosis, NF-κB, Autophagy

Tenuifoliside B

Cat.No: T5702

Target: Dehydrogenase

Cat.No: T24711

Synonym: 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,蓖麻碱,Ricinin,Ritsinin

Target: Others

4-methyl-6-phenyl-2H-pyranone

Cat.No: TN2436

Synonym: 4-methyl-6-phenyl-2H-pyranone

Target: Mitochondrial Metabolism

Palonosetron hydrochloride

Cat.No: T1156

Synonym: 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259

Target: 5-HT Receptor

Cat.No: TN4956

Target: NF-κB, MAPK

Beta-Tocopherol

Cat.No: TN1441

Synonym: β-生育酚,BETA-生育酚

Target: ERK, MAPK

Cat.No: TN1599

Synonym: Eburicoicacid,MFCD00238594,ZINC4655149,齿孔菌酸

Target: Antioxidant, TNF, NOS, NO Synthase, CCR, Immunology/Inflammation related

Cirsiumaldehyde

Cat.No: TN6975

Synonym: 5,5’-oxydimethylenebis(2-furfural)

Target: Platelet aggregation

Cat.No: T3717

Synonym: 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇

Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2

Cat.No: TN2354

Synonym: 3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷

Target: ERK, PDGFR

Neoisoliquiritin

Cat.No: TN1984

Target: Others

N-Methylnuciferine

Cat.No: TWS0704

Target: Others

N-Benzyllinoleamide

Cat.No: TN1353

Synonym: (9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺

Target: Others

Phenethyl ferulate

Cat.No: TN2330

Synonym: Caffeic Acid 3-Methyl Phenethyl Ester,阿魏酸苯乙酯,阿魏酸苯乙醇酯

Target: Lipoxygenase, COX

Cat.No: TMA1570

Target: NF-κB, Nrf2

Cat.No: TN1983

Target: IL Receptor, TNF, NO Synthase

Cat.No: TN1643

Synonym: 4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺

Target: PAFR, AChR

(20R)-Ginsenoside Rh1

Cat.No: T3793

Synonym: 20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1

Target: Others

Deoxyandrographolide

Cat.No: TQ0218

Synonym: 去氧穿心莲内酯,14-deoxyandrographolide

Target: IL Receptor, TNF

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00367	Chemerin/RARRES2 Protein, Mouse, Recombinant (His) AI303516,retinoic acid receptor responder (tazarotene in...	Mouse	HEK293 Cells
	Chemerin/RARRES2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is Q9DD06.
TMPY-01009	TGFBI Protein, Human, Recombinant (His) CDG2,CSD,EBMD,CSD1,CDGG1,CSD3,transforming growth factor, be...	Human	HEK293 Cells
	TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dys...
TMPY-01008	VEGFD Protein, Human, Recombinant (His) VEGFD,c-fos induced growth factor (vascular endothe...	Human	HEK293 Cells
	VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
TMPY-00005	FGF-8a Protein, Human, Recombinant fibroblast growth factor 8 (androgen-induced),FGF-8...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-06986	FGF-8b Protein, Human, Recombinant NEWENTRY,fibroblast growth factor 8 (androgen-induced	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-02603	STAT6 Protein, Human, Recombinant (His) STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t...	Human	Baculovirus Insect Cells
	Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators...
TMPJ-01084	CXCL9 Protein, Human, Recombinant (His) Monokine Induced by Interferon-γ,Gamma-Interferon-<...	Human	HEK293 Cells
	Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions by interacting with the chemokine receptor CXCR3. CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition. It is closely related t...
TMPJ-00884	CXCL9 Protein, Mouse, Recombinant (His) Protein m119,C-X-C motif chemokine 9,γ-interferon-induce...	Mouse	HEK293 Cells
	Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e...
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc) Insulin-induced gene 2 protein,INSIG2	Human	E. coli
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycho...
TMPJ-00981	PTX3 Protein, Mouse, Recombinant (His) alpha-induced protein 5,pentraxin 3, long,pentaxin-...	Mouse	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator...
TMPH-02032	GPRC5A Protein, Human, Recombinant (GST) G-protein coupled receptor family C group 5 member A,GPRC5A,...	Human	E. coli
	Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. GPRC5A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37.0 kDa and the accession number i...
TMPH-02291	ISG15 Protein, Human, Recombinant (Yeast, His) Ubiquitin cross-reactive protein,Interferon-induced...	Human	P. pastoris (Yeast)
	ISG15 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.5 kDa and the accession number is P05161.
TMPH-02963	ISG15 Protein, Mouse, Recombinant (His) Ubiquitin-like protein ISG15,Interferon-induced 17 ...	Mouse	P. pastoris (Yeast)
	ISG15 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 18.9 kDa and the accession number is Q64339.
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His) GG2-1,tumor necrosis factor, alpha-induced protein ...	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPJ-00607	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) Receptor activator of nuclear factor κ-B ligand,Osteoprotege...	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
TMPY-02841	Fragilis/IFITM3 Protein, Human, Recombinant (mFc) DSPA2b,1-8U,interferon induced transmembrane protei...	Human	HEK293 Cells
	Interferon-induced transmembrane protein 3 (IFITM3) belongs to the CD225 family. To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon-inducible transmembrane protein family members, IFITM1, 2, and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. IFITM3 is an IFN-induced anti...
TMPH-02793	Myocilin Protein, Mouse, Recombinant (His & Myc) Trabecular meshwork-induced glucocorticoid response...	Mouse	Baculovirus Insect Cells
	Myocilin Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.2 kDa and the accession number is O70624.
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Prote...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPH-02792	Myocilin Protein, Mouse, Recombinant (His) Myoc,Myocilin,Trabecular meshwork-induced glucocort...	Mouse	E. coli
	Myocilin Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is O70624.
TMPH-00378	Midkine Protein, Chicken, Recombinant (His & Myc) Midkine,RIHB,Retinoic acid-induced heparin-binding ...	Chicken	E. coli
	Has mitogenic activity, and neurite extension activity for PC12 cells. Midkine Protein, Chicken, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.9 kDa and the accession number is P24052.
TMPY-03200	VEGFD Protein, Rat, Recombinant (hFc) c-fos induced growth factor (vascular endothelial g...	Rat	HEK293 Cells
	VEGFD Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is O35251.
TMPY-04143	Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc) 0610007L05Rik,retinoic acid receptor responder (tazarotene <...	Mouse	HEK293 Cells
	Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.6 kDa and the accession number is Q9DD06.
TMPJ-00495	ISG15 Protein, Human, Recombinant (His) ISG15,Ubiquitin Cross-Reactive Protein,G1P2,Interferon-I...	Human	E. coli
	Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermed...
TMPH-01555	IFITM1 Protein, Human, Recombinant (GST) IFITM1,Leu-13 antigen,Dispanin subfamily A member 2a,Interfe...	Human	E. coli
	IFITM1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.0 kDa and the accession number is P13164.
TMPH-00084	Dehydrin Xero 2 Protein, Arabidopsis thaliana, Recombinant (His & Myc) Low-temperature-induced protein LTI30,LTI30,XERO2,D...	Arabidopsis thaliana	E. coli
	Dehydrin Xero 2 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.4 kDa and the accession number is P42758.
TMPJ-00433	VSIR Protein, Cynomolgus, Recombinant (His) Stress-induced secreted protein-1,Platelet receptor...	Cynomolgus	HEK293 Cells
	platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively.
TMPH-01548	IFI6 Protein, Human, Recombinant (B2M & His) Interferon-induced protein 6-16,IFI6,Interferon alp...	Human	E. coli
	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells.
TMPH-00625	FMN reductase Protein, E. coli, Recombinant (His) FMN reductase,ssuE,FMN reductase (NADPH),Sulfate starvation-...	E. coli	Baculovirus Insect Cells
	Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin.
TMPK-00660	AMIGO2 Protein, Cynomolgus, Recombinant (His) Alivin-1,AMIGO-2,DEGA,Amphotein-induced protein 2,a...	Cynomolgus	HEK293 Cells
	AMIGO2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.97 kDa and the accession number is G7PHN7.
TMPH-01912	PIBF1 Protein, Human, Recombinant (His & Myc) Progesterone-induced-blocking factor 1,PIBF1,Centro...	Human	E. coli
	PIBF1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02908	AICDA Protein, Mouse, Recombinant (His & Myc) Single-stranded DNA cytosine deaminase,Cytidine aminohydrola...	Mouse	E. coli
	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
TMPH-02311	WDR5 Protein, Human, Recombinant (His & SUMO) WDR5,BMP2-induced 3-kb gene protein,WD repeat-conta...	Human	E. coli
	WDR5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.5 kDa and the accession number is P61964.
TMPK-01072	AMIGO2 Protein, Mouse, Recombinant (His) ALI1,DEGA,Alivin-1,Amphotein-induced protein 2,aliv...	Mouse	HEK293 Cells
	AMIGO2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.8 kDa and the accession number is Q80ZD9.
TMPH-02641	ECEL1 Protein, Mouse, Recombinant (His & Myc) Ecel1,Endothelin-converting enzyme-like 1,Dine,Xce,Damage-	Mouse	E. coli
	May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
TMPH-02856	SAAL1 Protein, Mouse, Recombinant (His & Myc) Synoviocyte proliferation-associated in collagen-induced...	Mouse	E. coli
	Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
TMPH-02241	TMEM158 Protein, Human, Recombinant (His) TMEM158,Ras-induced senescence protein 1,40 kDa BIN...	Human	E. coli
	Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
TMPY-03150	VEGFD Protein, Mouse, Recombinant (His) VEGF-D,Vegfd,AI325264,c-fos induced growth factor (...	Mouse	HEK293 Cells
	VEGFD Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is P97946.
TMPY-02589	VEGFD Protein, Mouse, Recombinant (hFc) c-fos induced growth factor (vascular endothelial g...	Mouse	HEK293 Cells
	VEGFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P97946.
TMPJ-00338	LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated Leucine-rich repeat-containing protein 15,LIB,LRRC15,Leucine...	Human	HEK293 Cells
	The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions used for molecular recognition process such as cell adhesion, signal transduction, DNA repair, and RNA processing. The LRRC15 is also a transmembrane protein demonstrated to play important roles in cancer. LRRC15 expression was notably increased 4.6-fold in cariesdiseased pulpal t...
TMPH-02736	IFIH1 Protein, Mouse, Recombinant (His) Melanoma differentiation-associated protein 5,Helicase with ...	Mouse	E. coli
	IFIH1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q8R5F7.
TMPH-00077	IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc) IAA17,Auxin response 3,Indoleacetic acid-induced pr...	Arabidopsis thaliana	E. coli
	Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E....
TMPH-00930	Anamorsin Protein, Human, Recombinant (His & SUMO) CIAPIN1,Fe-S cluster assembly protein DRE2 homolog,Cytokine-...	Human	E. coli
	Anamorsin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q6FI81.
TMPJ-00320	AMIGO2 Protein, Human, Recombinant (hFc) DEGA,AMIGO-2,AMIGO2,ALI1,Alivin-1,Amphoterin-Induced	Human	HEK293 Cells
	Amphoterin-Induced Protein 2 (AMIGO2) is a single-pass type I membrane protein which belongs to the AMIGO family of immunoglobulin superfamily. Mature AMIGO2 contains an Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, a LRRCT domain, as well as a LRRNT domain. AMIGO2 is mainly expressed in in breast, ovary, cervix, and uterus, although lower in lung, colon, and rectum. AMIGO2 required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2...
TMPH-02510	ANGPTL8 Protein, Mouse, Recombinant (His) Rifl,Refeeding-induced fat and liver protein,Betatr...	Mouse	P. pastoris (Yeast)
	Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3. ANGPTL8 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 22.5 kDa and the...
TMPH-00774	SAM22 Protein, Glycine max, Recombinant (His) Pathogenesis-related protein 10,PR-10,Stress-induced	Glycine max	P. pastoris (Yeast)
	Involved in disease resistance. SAM22 Protein, Glycine max, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is P26987.
TMPH-02509	ANGPTL8 Protein, Mouse, Recombinant (E. coli, His) Angiopoietin-like protein 8,Lipasin,Gm6484,Refeeding-ind...	Mouse	E. coli
	Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.
TMPH-02919	SOCS1 Protein, Mouse, Recombinant (His & Myc) STAT-induced STAT inhibitor 1,Suppressor of cytokin...	Mouse	E. coli
	SOCS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is O35716.
TMPJ-00082	NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin ...	Mouse	HEK293 Cells
	Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig...
TMPJ-00110	GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His) Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis factor receptor su...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and...
TMPJ-00008	CXCL10 Protein, Human, Recombinant (hFc & His) INP10,10 kDa Interferon Gamma-Induced Protein,C-X-C...	Human	HEK293 Cells
	Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity.
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重组蛋白

Chemerin/RARRES2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00367

Species: Mouse

Expression System: HEK293 Cells

TGFBI Protein, Human, Recombinant (His)

Cat.No: TMPY-01009

Species: Human

Expression System: HEK293 Cells

VEGFD Protein, Human, Recombinant (His)

Cat.No: TMPY-01008

Species: Human

Expression System: HEK293 Cells

FGF-8a Protein, Human, Recombinant

Cat.No: TMPY-00005

Species: Human

Expression System: E. coli

FGF-8b Protein, Human, Recombinant

Cat.No: TMPY-06986

Species: Human

Expression System: E. coli

STAT6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02603

Species: Human

Expression System: Baculovirus Insect Cells

CXCL9 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01084

Species: Human

Expression System: HEK293 Cells

CXCL9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00884

Species: Mouse

Expression System: HEK293 Cells

INSIG2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01535

Species: Human

Expression System: E. coli

PTX3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00981

Species: Mouse

Expression System: HEK293 Cells

GPRC5A Protein, Human, Recombinant (GST)

Cat.No: TMPH-02032

Species: Human

Expression System: E. coli

ISG15 Protein, Human, Recombinant (Yeast, His)

Cat.No: TMPH-02291

Species: Human

Expression System: P. pastoris (Yeast)

ISG15 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02963

Species: Mouse

Expression System: P. pastoris (Yeast)

TNFAIP8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03416

Species: Human

Expression System: E. coli

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00607

Species: Mouse

Expression System: HEK293 Cells

Fragilis/IFITM3 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-02841

Species: Human

Expression System: HEK293 Cells

Myocilin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02793

Species: Mouse

Expression System: Baculovirus Insect Cells

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

Myocilin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02792

Species: Mouse

Expression System: E. coli

Midkine Protein, Chicken, Recombinant (His & Myc)

Cat.No: TMPH-00378

Species: Chicken

Expression System: E. coli

VEGFD Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03200

Species: Rat

Expression System: HEK293 Cells

Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04143

Species: Mouse

Expression System: HEK293 Cells

ISG15 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00495

Species: Human

Expression System: E. coli

IFITM1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01555

Species: Human

Expression System: E. coli

Dehydrin Xero 2 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00084

Species: Arabidopsis thaliana

Expression System: E. coli

VSIR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00433

Species: Cynomolgus

Expression System: HEK293 Cells

IFI6 Protein, Human, Recombinant (B2M & His)

Cat.No: TMPH-01548

Species: Human

Expression System: E. coli

FMN reductase Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00625

Species: E. coli

Expression System: Baculovirus Insect Cells

AMIGO2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00660

Species: Cynomolgus

Expression System: HEK293 Cells

PIBF1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01912

Species: Human

Expression System: E. coli

AICDA Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02908

Species: Mouse

Expression System: E. coli

WDR5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02311

Species: Human

Expression System: E. coli

AMIGO2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01072

Species: Mouse

Expression System: HEK293 Cells

ECEL1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02641

Species: Mouse

Expression System: E. coli

SAAL1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02856

Species: Mouse

Expression System: E. coli

TMEM158 Protein, Human, Recombinant (His)

Cat.No: TMPH-02241

Species: Human

Expression System: E. coli

VEGFD Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03150

Species: Mouse

Expression System: HEK293 Cells

VEGFD Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02589

Species: Mouse

Expression System: HEK293 Cells

LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00338

Species: Human

Expression System: HEK293 Cells

IFIH1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02736

Species: Mouse

Expression System: E. coli

IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00077

Species: Arabidopsis thaliana

Expression System: E. coli

Anamorsin Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00930

Species: Human

Expression System: E. coli

AMIGO2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00320

Species: Human

Expression System: HEK293 Cells

ANGPTL8 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02510

Species: Mouse

Expression System: P. pastoris (Yeast)

SAM22 Protein, Glycine max, Recombinant (His)

Cat.No: TMPH-00774

Species: Glycine max

Expression System: P. pastoris (Yeast)

ANGPTL8 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02509

Species: Mouse

Expression System: E. coli

SOCS1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02919

Species: Mouse

Expression System: E. coli

NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00082

Species: Mouse

Expression System: HEK293 Cells

GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)

Cat.No: TMPJ-00110

Species: Mouse

Expression System: HEK293 Cells

CXCL10 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00008

Species: Human

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
T70214	BMS-986202
	BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...
T71141	Fenspiride-d5
	Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
T71285	Metaxalone-d6
	Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ...
T71300	Pentoxifylline-d6
	Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg/...
T71145	Racecadotril-d5
	Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu...
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...
T71143	Ambroxol-d5
	Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part...
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
TMID-0287	Galanthamine-O-methyl-d3
	Galanthamine-O-methyl-d3 是 Galanthamine-O-methyl 的氘代化合物。Galanthamine-O-methyl 的 CAS 号为 357-70-0。Galanthamine 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。
TMIJ-0144	Palonosetron-d3 HCl
	Palonosetron-d3 HCl 是 Palonosetron HCl 的氘代化合物。Palonosetron HCl 的 CAS 号为 135729-62-3。Palonosetron hydrochloride 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...
T71326	1,3,7-Trimethyluric Acid-d9
	1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...
TMID-0198	Esmolol-d7 HCl
	Esmolol-d7 HCl 是 Esmolol HCl 的氘代化合物。Esmolol HCl 的 CAS 号为 81161-17-3。Esmolol hydrochloride 是一种心脏选择性β受体阻滞剂，用于治疗心律失常和严重高血压。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T71893	Clobetasol Propionate-d5
	Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t...
T71288	Phenylbutazone-d9
	Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...
T68918	Phenytoin-d10
	Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal...
T36383	L-Thyroxine-13C9,15N L-Thyroxine-13C9,15N
	L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode...
TMIJ-0404	Dibenz[a,h]anthracene-d14
	Dibenz[a,h]anthracene-d14 是 Dibenz[a,h]anthracene 的氘代化合物。Dibenz[a,h]anthracene 的 CAS 号为 53-70-3。Dibenz[a,h]anthracene诱导细菌DNA损伤和基因突变，并在几种哺乳动物细胞培养物中诱导基因突变和转化。
TMIJ-0162	Dexamethasone-d4
	Dexamethasone-d4 是 Dexamethasone 的氘代化合物。Dexamethasone 的 CAS 号为 50-02-2。Dexamethasone是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。在脂多糖诱导的巨噬细胞炎症反应中，它抑制含有炎性 microRNA-155 的外泌体的产生。
T70035	Tasimelteon-d5
	Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of no...
T71206	Tiagabine-d6 hydrochloride
	Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ...
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T71329	Theophylline-d6
	Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F...
T37608	Riluzole-13C,15N2 Riluzole-13C,15N2
	Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a...
T71984	Enrofloxacin-d5
	Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model...
T71306	Gemfibrozil-d6
	Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l...
T71205	Fosinopril-d7 sodium salt
	Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
TMIJ-0337	(24Rac)-Campesterol-d7
	(24Rac)-Campesterol-d7 是 (24Rac)-Campesterol 的氘代化合物。(24Rac)-Campesterol 的 CAS 号为 474-62-4。Campesterol是一种植物甾醇，具有降胆固醇和抗癌的活性。
T70174	Pirlindole-d4 HCl
	Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru...
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...
TMIJ-0198	Taurochenodeoxycholic Acid-d5 Sodium Salt
	Taurochenodeoxycholic Acid-d5 Sodium Salt 是 Taurochenodeoxycholic Acid Sodium Salt 的氘代化合物。Taurochenodeoxycholic Acid Sodium Salt 的 CAS 号为 6009-98-9。Taurochenodeoxycholic acid sodium 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T71327	Paraxanthine-d6
	Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni...
T69598	Isoproterenol-d7 HCl
	Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom...
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...
TMIJ-0204	Betamethasone-d10 Dipropionate
	Betamethasone-d10 Dipropionate 是 Betamethasone Dipropionate 的氘代化合物。Betamethasone Dipropionate 的 CAS 号为 5593-20-4。Betamethasone dipropionate 是糖皮质激素类固醇，具有免疫抑制、抗炎作用。
TMIJ-0519	Fosaprepitant-d4 Dimeglumine
	Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
T35695	Oleic Acid-13C
	Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T71293	Nifuroxazide-d4
	Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S...
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
TMID-0116	Carbamazepine-10,11-epoxide-d10 (rings-d10)
	Carbamazepine-10,11-epoxide-d10 (rings-d10) 是 Carbamazepine-10,11-epoxide 的氘代化合物。Carbamazepine-10,11-epoxide 的 CAS 号为 36507-30-9。Carbamazepine 10,11-epoxide是抗惊厥药卡马西平 (carbamazepine) 的活性代谢物。它由卡马西平通过微粒体中的细胞色素 P450 (CYP) 同种型 CYP3A4 和 CYP2C8 形成，微粒体分别由表达 CYP3A4 或 CYP2C8 的 HepG2 细胞制备。它对小鼠最大电击诱发的癫痫发作具有抗惊厥活性。
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
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同位素标记化合物

Cat.No: T70214

Cat.No: T71981

Cat.No: T71141

Cat.No: T71212

Cat.No: T71285

Pentoxifylline-d6

Cat.No: T71300

Racecadotril-d5

Cat.No: T71145

Maprotiline-d3 hydrochloride

Cat.No: T70960

Cat.No: T71143

Flufenamic Acid-d4

Cat.No: T71303

Galanthamine-O-methyl-d3

Cat.No: TMID-0287

Palonosetron-d3 HCl

Cat.No: TMIJ-0144

Cat.No: T69966

Ethacrynic acid D5

Cat.No: T11240

Target: Others

1,3,7-Trimethyluric Acid-d9

Cat.No: T71326

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

Cat.No: TMID-0198

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Clobetasol Propionate-d5

Cat.No: T71893

Phenylbutazone-d9

Cat.No: T71288

Cat.No: T68918

L-Thyroxine-13C9,15N

Cat.No: T36383

Synonym: L-Thyroxine-13C9,15N

Dibenz[a,h]anthracene-d14

Cat.No: TMIJ-0404

Dexamethasone-d4

Cat.No: TMIJ-0162

Cat.No: T70035

Tiagabine-d6 hydrochloride

Cat.No: T71206

Cat.No: T71065

Theophylline-d6

Cat.No: T71329

Riluzole-13C,15N2

Cat.No: T37608

Synonym: Riluzole-13C,15N2

Enrofloxacin-d5

Cat.No: T71984

Cat.No: T71306

Fosinopril-d7 sodium salt

Cat.No: T71205

(24Rac)-Campesterol-d7

Cat.No: TMIJ-0337

Pirlindole-d4 HCl

Cat.No: T70174

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

Taurochenodeoxycholic Acid-d5 Sodium Salt

Cat.No: TMIJ-0198

Cat.No: T36408

Synonym: Rhein-13C4

Paraxanthine-d6

Cat.No: T71327

Isoproterenol-d7 HCl

Cat.No: T69598

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Betamethasone-d10 Dipropionate

Cat.No: TMIJ-0204

Fosaprepitant-d4 Dimeglumine

Cat.No: TMIJ-0519

Cat.No: T35695

Methazolamide-d6

Cat.No: T70186

Nicotinamide-d4

Cat.No: T69395

Nifuroxazide-d4

Cat.No: T71293

Cat.No: T71328

Carbamazepine-10,11-epoxide-d10 (rings-d10)

Cat.No: TMID-0116

Cat.No: T69600

Cat.No: T71402

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