CXCR2-IN-2

Name: CXCR2-IN-2
Brand: TargetMol
SKU: T36923
Price: 546 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T36923Cas号 1838123-21-9

别名 CXCR2-IN-2

CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].

CXCR2-IN-2

还可以

产品编号 T36923 别名 CXCR2-IN-2Cas号 1838123-21-9

规格	价格	库存
2 mg	¥ 2,890	5日内发货
5 mg	¥ 3,320	5日内发货
25 mg	¥ 13,900	8-10周
50 mg	¥ 18,300	8-10周
100 mg	¥ 25,500	8-10周
1 mL x 10 mM (in DMSO)	¥ 3,840	5日内发货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the β-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-fold selectivity over CXCR1 and greater than 1900-fold selectivity over all other chemokine receptors. Furthermore, CXCR2-IN-2 effectively inhibits Gro-α induced CD11b expression in human whole blood, displaying an IC50 of 0.04 μM[1].
靶点活性	CXCR2:5.2 nM (IC50), CXCR1:3.8 μM (IC50)
体内活性	CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1].
别名	CXCR2-IN-2

化学信息

分子量	414.9
分子式	C₁₈H₂₃ClN₂O₅S
CAS No.	1838123-21-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 240 mg/mL (578.45 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.4102 mL	12.0511 mL	24.1022 mL	120.5110 mL
5 mM	0.4820 mL	2.4102 mL	4.8204 mL	24.1022 mL
10 mM	0.2410 mL	1.2051 mL	2.4102 mL	12.0511 mL
20 mM	0.1205 mL	0.6026 mL	1.2051 mL	6.0255 mL
50 mM	0.0482 mL	0.2410 mL	0.4820 mL	2.4102 mL
100 mM	0.0241 mL	0.1205 mL	0.2410 mL	1.2051 mL