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HDAC6-IN-37(compound W5)是HDAC6的抑制剂,具有神经保护作用。HDAC6-IN-37可恢复海马神经元形态,减少AD大鼠海马中Aβ、Tau、p-Tau蛋白的表达,抑制老年斑和神经原纤维缠结的形成。因此,HDAC6-IN-37能够改善Aβ/Cu2+诱导的AD大鼠模型,调节氧化应激状态,并平衡脑组织中的神经递质紊乱。
HDAC6-IN-37(compound W5)是HDAC6的抑制剂,具有神经保护作用。HDAC6-IN-37可恢复海马神经元形态,减少AD大鼠海马中Aβ、Tau、p-Tau蛋白的表达,抑制老年斑和神经原纤维缠结的形成。因此,HDAC6-IN-37能够改善Aβ/Cu2+诱导的AD大鼠模型,调节氧化应激状态,并平衡脑组织中的神经递质紊乱。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | HDAC6-IN-37 (compound W5), an HDAC6 inhibitor, exhibits neuroprotective properties. It effectively restores the morphology of hippocampal neurons and diminishes the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats. Additionally, it prevents the formation of senile plaques and neurofibrillary tangles. Consequently, HDAC6-IN-37 ameliorates the symptoms in the Aβ/Cu 2+ -induced AD rat model, regulates oxidative stress, and restores balance to neurotransmitter levels in brain tissue [1]. |
分子量 | 385.87 |
分子式 | C19H16ClN3O2S |
CAS No. | 2986486-82-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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