Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a peptide known for its strong hypotensive effects and inhibition of catecholamine release from chromaffin cells without competing with other substances. It effectively suppresses catecholamine secretion in PC12 pheochromocytoma cells with an IC50 of 350 nM and prevents the desensitization of nicotinic cholinergic agonist-induced catecholamine release and nicotinic signal transduction, with an EC50 of approximately 270 nM for desensitization blockade, as evidenced by inhibited 22 Na+ uptake [1].