Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular endothelial cells (VEC) from oxLDL and HG-induced injury, offering potential therapeutic benefits for the prevention and treatment of atherosclerosis [1].

Nrf2激活剂-9（compound D-36）（5 μM、10 μM；6 h）成功地逆转了50 μg/mL oxLDL所诱导的HUVEC细胞凋亡现象[1]。同一化合物，在相同的浓度和暴露时间（6 h、24 h）下，促进了Nrf2在细胞内的核内迁移，并激活了Nrf2的抗氧化途径，从而对HUVEC细胞产生了保护作用[1]。