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ZX782 作为GPX4蛋白的降解剂和(Ferroptosis)铁死亡诱导剂,通过泛素蛋白酶体及自噬溶酶体降解GPX4,从而在HT1080细胞中显著增加脂质活性氧(ROS)的积累。
ZX782 作为GPX4蛋白的降解剂和(Ferroptosis)铁死亡诱导剂,通过泛素蛋白酶体及自噬溶酶体降解GPX4,从而在HT1080细胞中显著增加脂质活性氧(ROS)的积累。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells. |
分子量 | 750.28 |
分子式 | C39H48ClN5O8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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