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Amifostine thiol (WR-1065) 是放射保护剂,可保护 DNA 免受快速中子诱导的链断裂。Amifostine thiol 以剂量依赖性方式改善 (P<0.001) 6-OHDA 诱导的僵滞,通过 JNK 依赖的信号通路激活 p53。
Amifostine thiol (WR-1065) 是放射保护剂,可保护 DNA 免受快速中子诱导的链断裂。Amifostine thiol 以剂量依赖性方式改善 (P<0.001) 6-OHDA 诱导的僵滞,通过 JNK 依赖的信号通路激活 p53。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 198 | 现货 | |
2 mg | ¥ 278 | 现货 | |
5 mg | ¥ 463 | 现货 | |
10 mg | 询价 | 现货 |
产品描述 | Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway. |
体外活性 | 4 mM Amifostine thiol 对 X 射线辐照 30 min 诱导的基因组不稳定性具有一定保护作用,同时也能保护 RKO36 细胞免受电离辐射引起的染色体损伤和死亡[1]。 |
别名 | 氨磷汀硫化物, WR-1065 |
分子量 | 134.24 |
分子式 | C5H14N2S |
CAS No. | 31098-42-7 |
Smiles | NCCCNCCS |
存储 | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 80 mg/mL (595.9 mM), Sonication is recommended. DMSO: 200 mg/mL (1.49 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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