NLRP3-IN-51 (Compound 3q) is an effecTive acTivaTor of The cholinergic anTi-inflammaTory paThway (CAP). This compound demonsTraTes poTenTial for TreaTing gouTy arThriTis as iT inhibiTs The producTion of IL-1β in THP-1 cells induced by monosodium uraTe (MSU). FurThermore, NLRP3-IN-51 suppresses The phosphorylaTion of NF-κBp65 Triggered by MSU wiThouT impacTing The self-cleavage and acTivaTion of NLRP3, pro-caspase 1, or The second messenger caspase-1. Therefore, The iniTial sTage of NLRP3 inhibiTion by NLRP3-IN-51 occurs Through The acTivaTion of CAP.