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Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。
Calcium dobesilate 具有血管保护特性,部分通过改善 HG 诱导的炎症来保护内皮细胞,用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 415 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 161 | 现货 |
产品描述 | Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG induced inflammation. |
体外活性 | CaD inhibited abnormal cell proliferation. high glucose (HG) treatment also significantly enhanced HVUEC migration compared to the control treatment. In contrast, CaD treatment partially inhibited HUVEC migration compared to HG exposure. HG?treated HUVECs exhibited increased FITC?BSA permeability compared to control cells cultured in medium alone; however, CaD application prevented the HG?induced increase in FITC?BSA permeability and suppressed HG?induced overexpression of endothelial markers (VEGF, VEGFR?2, endocan) and inflammation markers (ICAM?1, MCP?1, PTX3) in HUVECs. CaD has angioprotective properties and protects endothelial cells partly by ameliorating HG?induced inflammation[1]. |
细胞实验 | HUVECs were seeded in 96-well culture plates (1×10^4 cells/well). Following 24 h, the control or experimental medium was added. At 12, 24, 48 and 72 h, 10 μl CCK-8 reagent was added to each well for 1 h. Absorbance values were recorded at a wavelength of 450 nm using a microplate reader[1]. |
别名 | 羟苯磺酸钙 |
分子量 | 229.2 |
分子式 | C6H5O5SCa0.5 |
CAS No. | 20123-80-2 |
Smiles | [Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc1ccc(O)c(c1)S([O-])(=O)=O |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (218.15 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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