Ebselen derivative 1 (Compound 19), an orally active glutathione peroxidase (GPx) mimic, exhibits notable protective effects against cisplatin-induced hair cell (HC) damage in both in vitro and in vivo settings. It significantly reduces oxidative stress, apoptosis, and ferroptosis in hair cells, making it useful in the study of cisplatin-induced hearing loss [1].

Ebselen derivative 1 (Compound 19) (100 μM) 在毛细胞内降低了由顺铂引发的凋亡与铁死亡，同时减轻了顺铂在耳蜗范围内激发的氧化应激的激增 [1]。

在 C57BL/6 小鼠中，Ebselen derivative 1 (Compound 19) (80 mg/kg; 口服; 一天一次连续一周) 具有听力保护作用，可缓解顺铂 (5 mg/kg; 腹腔注射; 在 Ebselen derivative 1 给药的第三天和第七天各一次) 诱导的毛细胞损失 [1]。