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Vasculotide, 一种Angiopoietin-1类似物,具有激活Tie-2并诱导其磷酸化的能力.此外,Vasculotide也表现出抗炎及抗渗透的特性.它能够改善由内毒素引起的内皮屏障功能障碍,促进小鼠糖尿病溃疡模型中的血管生成,并在小鼠模型中保护血管免受渗漏,从而降低腹腔脓毒症的死亡率.此外,Vasculotide在大鼠出血性休克模型中减少微血管渗漏,改善微循环灌注.
Vasculotide, 一种Angiopoietin-1类似物,具有激活Tie-2并诱导其磷酸化的能力.此外,Vasculotide也表现出抗炎及抗渗透的特性.它能够改善由内毒素引起的内皮屏障功能障碍,促进小鼠糖尿病溃疡模型中的血管生成,并在小鼠模型中保护血管免受渗漏,从而降低腹腔脓毒症的死亡率.此外,Vasculotide在大鼠出血性休克模型中减少微血管渗漏,改善微循环灌注.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Vasculotide, an angiopoietin-1 analog, functions as a Tie-2 activator that induces Tie-2 phosphorylation. This compound exhibits anti-inflammatory properties and enhances vascular permeability. It effectively improves endothelial barrier dysfunction induced by endotoxins and promotes angiogenesis in mouse models of diabetic ulcers. Furthermore, Vasculotide protects mice from vascular leakage and reduces mortality in mouse models of abdominal sepsis. Additionally, it decreases microvascular leakage and improves microcirculation perfusion in rat models of hemorrhagic shock. |
CAS No. | 1359657-45-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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