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LQB-118,一种口服活性的紫檀醌,能有效抑制胶质母细胞瘤细胞迁移并诱导细胞凋亡。此外,LQB-118还能通过调控AKT/GSK3β通路及MMP-9/reck基因表达来抑制前列腺癌细胞的迁移与侵袭。在体外及体内实验中,该化合物可抑制由酵母聚糖引发的炎症反应。特别是在Leishmania amazonensis中,LQB-118可选择性地诱导ROS生成和依赖于线粒体的细胞凋亡 (apoptosis),使其在研究炎症、感染以及肿瘤疾病方面显示出应用潜力。
LQB-118,一种口服活性的紫檀醌,能有效抑制胶质母细胞瘤细胞迁移并诱导细胞凋亡。此外,LQB-118还能通过调控AKT/GSK3β通路及MMP-9/reck基因表达来抑制前列腺癌细胞的迁移与侵袭。在体外及体内实验中,该化合物可抑制由酵母聚糖引发的炎症反应。特别是在Leishmania amazonensis中,LQB-118可选择性地诱导ROS生成和依赖于线粒体的细胞凋亡 (apoptosis),使其在研究炎症、感染以及肿瘤疾病方面显示出应用潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | LQB-118, an orally active compound sourced from sandalwood, demonstrates multiple therapeutic capabilities. It has shown proficiency in inhibiting glioblastoma cell migration and inducing apoptosis. Additionally, LQB-118 can curtail both migration and invasion of prostate cancer cells by modulating the AKT/GSK3β pathway and regulating MMP-9/reck gene expression. The compound is also effective against yeast polysaccharide-induced inflammation in both in vivo and in vitro settings. Notably, LQB-118 specifically triggers ROS-mediated and mitochondrial-dependent apoptosis in Leishmania amazonensis, highlighting its potential in studies focusing on inflammation, infections, and various cancers. |
分子量 | 304.3 |
分子式 | C19H12O4 |
CAS No. | 1219104-20-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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